Eduardo Lazcano-Ponce1, Jorge Salmerón2, Andrea González3, Betania Allen-Leigh1, Leith León-Maldonado4, Carlos Magis5, Carlos Aranda-Flores6, Carlos Conde-González1, Alejandra Jalil Portillo-Romero4, Elsa Yunes-Díaz1, Leonor Rivera-Rivera1, Galileo Vargas3, Alan G Nyitray7, Anna R Giuliano8. 1. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, México. 2. Centro de Investigación en Políticas, Población y Salud, Universidad Nacional Autónoma de México. Ciudad de México, México. 3. Centro para la Prevención y Atención Integral del VIH/Sida de la Ciudad de México, Clínica Condesa. Ciudad de México, México. 4. Cátedra Conacyt, Instituto Nacional de Salud Pública. Cuernavaca, México. 5. Centro Nacional para la Prevención y Control del VIH y el Sida. Ciudad de México, México. 6. Departamento de Oncología, Hospital General de la Ciudad de México. Mexico. 7. Center for Infectious Diseases, The University of Texas School of Public Health at Houston. TX, USA. 8. Center for Infection in Cancer Research, Moffitt Cancer Center.Tampa, FL, USA.
Abstract
OBJECTIVE: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of anogenital and oropharyngeal neoplasms among men who have sex with men, people with HIV, homeless people, transgender women, female sex workers and rape victims. MATERIALS AND METHODS: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, using Kaplan-Meier. The time-to-event method will evaluate time from positive results for specific anogenital HPV to incidence of anogenital lesions containing that HPV type. RESULTS: People vaccinated against HPV and screened for HPV as a primary test will have lower prevalence and incidence of HPV infection and consequently lower frequency of HPV-related anogenital and oropharyngeal lesions. CONCLUSIONS: Thisstudy will generate scientific evidence on effectiveness of a combined vaccination-screening strategy to reduce the burden of HPV-associated neoplasms.
OBJECTIVE: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of anogenital and oropharyngeal neoplasms among men who have sex with men, people with HIV, homeless people, transgender women, female sex workers and rape victims. MATERIALS AND METHODS: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, using Kaplan-Meier. The time-to-event method will evaluate time from positive results for specific anogenital HPV to incidence of anogenital lesions containing that HPV type. RESULTS: People vaccinated against HPV and screened for HPV as a primary test will have lower prevalence and incidence of HPV infection and consequently lower frequency of HPV-related anogenital and oropharyngeal lesions. CONCLUSIONS: Thisstudy will generate scientific evidence on effectiveness of a combined vaccination-screening strategy to reduce the burden of HPV-associated neoplasms.
Entities:
Keywords:
Condesa Study; HPV vaccines; Mexico; cancer screening
Authors: L León-Maldonado; A Cabral; B Brown; G W Ryan; A Maldonado; J Salmerón; B Allen-Leigh; E Lazcano-Ponce Journal: Hum Vaccin Immunother Date: 2019-07-10 Impact factor: 3.452
Authors: Alejandra J Portillo-Romero; Betania Allen-Leigh; Alan G Nyitray; Martha Carnalla; Jorge Salmerón; Leith León-Maldonado; Elsa Yunes; Leonor Rivera; Carlos Magis-Rodríguez; Galileo Vargas; Anna R Giuliano; Eiberth A Esquivel-Ocampo; Eduardo Lazcano-Ponce Journal: Transgend Health Date: 2021-12-02
Authors: Rosibel Rodríguez-Bolaños; Ricardo Baruch-Dominguez; Edna Arillo-Santillán; Elsa Yunes-Díaz; Leonor Rivera-Rivera; Lizeth Cruz-Jiménez; James F Thrasher; Alan G Nyitray; Eduardo Lazcano-Ponce Journal: Int J Environ Res Public Health Date: 2022-07-21 Impact factor: 4.614