Literature DB >> 30698874

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety.

Victoria A Snaidr1, Diona L Damian1,2, Gary M Halliday1.   

Abstract

Nicotinamide is a water-soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinamide in dermatology and its actions in preventing photoageing and skin cancers in humans. Nicotinamide prevents ultraviolet radiation (UV) from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation-induced energy crisis. This enhances DNA repair and reduces UV-induced suppression of immunity. Randomised controlled clinical trials have also shown that nicotinamide reduces transepidermal water loss and the development of new non-melanoma skin cancers in high-risk humans. This review also examines nicotinamide's safety profile.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  actinic keratosis; niacinamide; non-melanoma skin cancer; transplant patients

Mesh：

Substances：

Year:  2019        PMID： 30698874     DOI： 10.1111/exd.13819

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  14 in total

Review 1.  Focus on the Contribution of Oxidative Stress in Skin Aging.

Authors:  Federica Papaccio; Andrea D Arino; Silvia Caputo; Barbara Bellei
Journal:  Antioxidants (Basel)       Date:  2022-06-06

Review 2.  Oral nicotinamide for non-melanoma skin cancers: A review.

Authors:  Samantha Vicki Hunt; Aaron Jamison; Raman Malhotra
Journal:  Eye (Lond)       Date:  2022-03-28       Impact factor: 4.456

Review 3.  TGFβ Signaling in Photoaging and UV-Induced Skin Cancer.

Authors:  Yao Ke; Xiao-Jing Wang
Journal:  J Invest Dermatol       Date:  2021-01-07       Impact factor: 8.551

Review 4.  Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.

Authors:  Eun Seong Hwang; Seon Beom Song
Journal:  Biomolecules       Date:  2020-04-29

Review 5.  Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.

Authors:  Luca Fania; Cinzia Mazzanti; Elena Campione; Eleonora Candi; Damiano Abeni; Elena Dellambra
Journal:  Int J Mol Sci       Date:  2019-11-26       Impact factor: 5.923

6.  Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter.

Authors:  Ao Xuan Zhen; Mei Jing Piao; Kyoung Ah Kang; Pincha Devage Sameera Madushan Fernando; Hee Kyoung Kang; Young Sang Koh; Joo Mi Yi; Jin Won Hyun
Journal:  Biomol Ther (Seoul)       Date:  2019-07-05       Impact factor: 4.634

7.  Enhanced NAMPT-Mediated NAD Salvage Pathway Contributes to Psoriasis Pathogenesis by Amplifying Epithelial Auto-Inflammatory Circuits.

Authors:  Laura Mercurio; Martina Morelli; Claudia Scarponi; Giovanni Luca Scaglione; Sabatino Pallotta; Daniele Avitabile; Cristina Albanesi; Stefania Madonna
Journal:  Int J Mol Sci       Date:  2021-06-25       Impact factor: 5.923

Review 8.  Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma.

Authors:  Terenzio Cosio; Monia Di Prete; Elena Campione
Journal:  Biomedicines       Date:  2020-06-11

Review 9.  The Role of Nicotinamide in Cancer Chemoprevention and Therapy.

Authors:  Ilias P Nikas; Stavroula A Paschou; Han Suk Ryu
Journal:  Biomolecules       Date:  2020-03-20

10.  Topical Delivery of Niacinamide: Influence of Binary and Ternary Solvent Systems.

Authors:  Yanling Zhang; Chin-Ping Kung; Bruno C Sil; Majella E Lane; Jonathan Hadgraft; Michael Heinrich; Balint Sinko
Journal:  Pharmaceutics       Date:  2019-12-10       Impact factor: 6.321
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