Jinjun Cheng1, Meiling Zhang1, Ziwei Sun1, Fang Lu1, Wei Xiong2, Juan Luo2, Hui Kong1, Qingguo Wang1, Huihua Qu3, Yan Zhao1. 1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. 2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China. 3. Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Abstract
AIM: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). MATERIALS & METHODS: The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. RESULTS: The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. CONCLUSION: The JMC-CDs may have great potentials in clinical practice.
AIM: To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). MATERIALS & METHODS: The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by Deinagkistrodon acutus venom. RESULTS: The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. CONCLUSION: The JMC-CDs may have great potentials in clinical practice.