Literature DB >> 30698442

Synthesis of Spirooxindoles from N-Arylamide Derivatives via Oxidative C(sp2)-C(sp3) Bond Formation Mediated by PhI(OMe)2 Generated in Situ.

Xiaohua Zhen1, Xintong Wan1, Wei Zhang1, Qiao Li1, Daisy Zhang-Negrerie1, Yunfei Du1,2.   

Abstract

A class of novel spirooxindole compounds (2) were readily synthesized, in a metal-free environment, from N-arylamide derivatives (1) via intramolecular oxidative cyclization. Direct oxidative C(sp2)-C(sp3) bond formation was realized with the least-studied PhI(OMe)2 as an oxidant, formed in situ from the reaction between PhIO and MeOH.

Entities:  

Year:  2019        PMID： 30698442     DOI： 10.1021/acs.orglett.8b03741

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A.

Authors:  Qiao Li; Chen Zhuang; Donghua Wang; Wei Zhang; Rongxuan Jia; Fengxia Sun; Yilin Zhang; Yunfei Du
Journal:  Beilstein J Org Chem       Date:  2019-12-12       Impact factor: 2.883

Review 2.  IBX-Mediated Organic Transformations in Heterocyclic Chemistry-A Decade Update.

Authors:  Yadavalli Venkata Durga Nageswar; Katla Ramesh; Katla Rakhi
Journal:  Front Chem       Date:  2022-02-28       Impact factor: 5.221
  2 in total

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