M Maltais1, P de Souto Barreto, Y Rolland, B Vellas. 1. Mathieu Maltais, PhD, Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, 37 allée Jules Guesde, 31000, Toulouse France, Phone : (+33) 05 61 14 56 91, E-mail : mathieu.maltais@usherbrooke.ca.
Abstract
OBJECTIVES: The objective of this study was to examine the relationship of fat mass (FM) with brain amyloid (Aβ) load in older adults. METHODS: Data from the Multidomain Alzheimer's Preventive Trial (MAPT) for Positron emission tomography and dual-energy X-ray absorptiometry (DXA) were used. Linear regressions controlling for appendicular muscle, age, education, clinical dementia rating scale and Apolipoprotein-E were performed to explore the relationships between FM, trunk FM and Aβ-load. RESULTS: Thirty-nine participants (75.7 ± 4.2 years old) with an average BMI of 27.5 ± 4.0 kg/m2 were analyzed in this study. There were significant and positive associations of both total and trunk FM with Aβ load [0.01 (0.002-0.02) and 0.02 (0.001-0.04), respectively]; however, when adding ApoE-ε4 as a confounder, associations were no longer significant. CONCLUSIONS: This study has found associations between FM as measured by DXA and cerebral Aβ load, suggesting that excessive FM might be involved in AD pathology.
OBJECTIVES: The objective of this study was to examine the relationship of fat mass (FM) with brain amyloid (Aβ) load in older adults. METHODS: Data from the Multidomain Alzheimer's Preventive Trial (MAPT) for Positron emission tomography and dual-energy X-ray absorptiometry (DXA) were used. Linear regressions controlling for appendicular muscle, age, education, clinical dementia rating scale and Apolipoprotein-E were performed to explore the relationships between FM, trunk FM and Aβ-load. RESULTS: Thirty-nine participants (75.7 ± 4.2 years old) with an average BMI of 27.5 ± 4.0 kg/m2 were analyzed in this study. There were significant and positive associations of both total and trunk FM with Aβ load [0.01 (0.002-0.02) and 0.02 (0.001-0.04), respectively]; however, when adding ApoE-ε4 as a confounder, associations were no longer significant. CONCLUSIONS: This study has found associations between FM as measured by DXA and cerebral Aβ load, suggesting that excessive FM might be involved in AD pathology.
Authors: Kelly A Volcik; Ruth Ann Barkley; Richard G Hutchinson; Thomas H Mosley; Gerardo Heiss; A Richey Sharrett; Christie M Ballantyne; Eric Boerwinkle Journal: Am J Epidemiol Date: 2006-06-07 Impact factor: 4.897
Authors: Annette L Fitzpatrick; Lewis H Kuller; Oscar L Lopez; Paula Diehr; Ellen S O'Meara; W T Longstreth; José A Luchsinger Journal: Arch Neurol Date: 2009-03