Literature DB >> 30697463

Preclinical PET tracers for the evaluation of sarcomas: understanding tumor biology.

Ian R Sigal1, Ronnie Sebro1,2,3,4.   

Abstract

Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. 18F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. 18F-FDG PET maximum SUV has been shown to be correlated with sarcoma grade and overall survival. This has led to interest in alternative PET tracers to assess the biological characteristics of tumors and guide treatment decisions. Here we investigate novel PET/CT tracers used for the evaluation of sarcomas over the past 20 years and summarize what we have learned about sarcoma tumor biology from these studies.

Entities:  

Keywords:  PET; amino acid PET tracers; hypoxia imaging; nucleoside PET tracers; sarcoma

Year:  2018        PMID： 30697463      PMCID： PMC6334210     

Source DB:  PubMed          Journal:  Am J Nucl Med Mol Imaging


  57 in total

1.  Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.

Authors:  Stefan S Bielack; Beate Kempf-Bielack; Günter Delling; G Ulrich Exner; Silke Flege; Knut Helmke; Rainer Kotz; Mechthild Salzer-Kuntschik; Matthias Werner; Winfried Winkelmann; Andreas Zoubek; Heribert Jürgens; Kurt Winkler
Journal:  J Clin Oncol       Date:  2002-02-01       Impact factor: 44.544

2.  Preclinical evaluation of 4-[18F]fluoroprolines: diastereomeric effect on metabolism and uptake in mice.

Authors:  H J Wester; M Herz; R Senekowitsch-Schmidtke; M Schwaiger; G Stöcklin; K Hamacher
Journal:  Nucl Med Biol       Date:  1999-04       Impact factor: 2.408

3.  Protein synthesis rate measured with L-[1-11C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas.

Authors:  B Plaat; A Kole; M Mastik; H Hoekstra; W Molenaar; W Vaalburg
Journal:  Eur J Nucl Med       Date:  1999-04

4.  Synthesis and evaluation of O-(3-[18F]fluoropropyl)-L-tyrosine as an oncologic PET tracer.

Authors:  Ganghua Tang; Mingfang Wang; Xiaolan Tang; Lei Luo; Manquan Gan
Journal:  Nucl Med Biol       Date:  2003-10       Impact factor: 2.408

5.  L-[1-11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer.

Authors:  R J van Ginkel; A C Kole; O E Nieweg; W M Molenaar; J Pruim; H S Koops; W Vaalburg; H J Hoekstra
Journal:  J Nucl Med       Date:  1999-02       Impact factor: 10.057

6.  Tumour oxygenation assessed by 18F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours.

Authors:  Lise Bentzen; Susanne Keiding; Marianne Nordsmark; Lise Falborg; Søren B Hansen; Johnny Keller; Ole S Nielsen; Jens Overgaard
Journal:  Radiother Oncol       Date:  2003-06       Impact factor: 6.280

7.  [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors.

Authors:  Dietlind Sorger; Marianne Patt; Piyush Kumar; Leonard I Wiebe; Henryk Barthel; Anita Seese; Claudia Dannenberg; Andrea Tannapfel; Regine Kluge; Osama Sabri
Journal:  Nucl Med Biol       Date:  2003-04       Impact factor: 2.408

8.  A statistical measure of tissue heterogeneity with application to 3D PET sarcoma data.

Authors:  Finbarr O'Sullivan; Supratik Roy; Janet Eary
Journal:  Biostatistics       Date:  2003-07       Impact factor: 5.899

9.  [(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression.

Authors:  J G Rajendran; D C Wilson; E U Conrad; L M Peterson; J D Bruckner; J S Rasey; L K Chin; P D Hofstrand; J R Grierson; J F Eary; K A Krohn
Journal:  Eur J Nucl Med Mol Imaging       Date:  2003-03-11       Impact factor: 9.236

10.  Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis.

Authors:  Janet F Eary; Finbarr O'Sullivan; Yudi Powitan; Kingshuk Roy Chandhury; Cheryl Vernon; James D Bruckner; Ernest U Conrad
Journal:  Eur J Nucl Med Mol Imaging       Date:  2002-06-19       Impact factor: 9.236
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  1 in total

Review 1.  Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging.

Authors:  Nicolò Gennaro; Andrea Marrari; Salvatore Lorenzo Renne; Ferdinando Carlo Maria Cananzi; Vittorio Lorenzo Quagliuolo; Lucia Di Brina; Marta Scorsetti; Giovanna Pepe; Arturo Chiti; Armando Santoro; Luca Balzarini; Letterio Salvatore Politi; Alexia Francesca Bertuzzi
Journal:  Br J Radiol       Date:  2020-06-26       Impact factor: 3.039
  1 in total

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