Literature DB >> 3069577

[Mutability of LYS2 gene in diploid Saccharomyces yeasts. II. Frequency of mutants induced by 6-N-hydroxylaminopurine and propiolactone].

Iu I Pavlov, V N Noskov, Iu O Chernov, D A Gordenin.   

Abstract

Chemical mutagens 6-N-hydroxylaminopurine (HAP) and propiolactone (PRO) induce Lys2 mutants with high frequency in diploid yeast Saccharomyces cerevisiae. HAP induces such mutants even in tetraploid strains. The genetic analysis of mutants was performed. It is shown that PRO induces mutants by means of "mutation-mitotic segregation" mechanism, while HAP induces mutants through novel mechanism "both allele mutation". Manifestation of such mechanism is the null fertility after meiosis of diploid mutants induced by HAP.

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Year:  1988        PMID： 3069577

Source DB:  PubMed          Journal:  Genetika        ISSN： 0016-6758


  6 in total

1.  Deletion of the DEF1 gene does not confer UV-immutability but frequently leads to self-diploidization in yeast Saccharomyces cerevisiae.

Authors:  E I Stepchenkova; A A Shiriaeva; Y I Pavlov
Journal:  DNA Repair (Amst)       Date:  2018-08-23

2.  The yeast HSM3 gene acts in one of the mismatch repair pathways.

Authors:  I V Fedorova; L M Gracheva; S V Kovaltzova; T A Evstuhina; S Y Alekseev; V G Korolev
Journal:  Genetics       Date:  1998-03       Impact factor: 4.562

3.  Volatility of Mutator Phenotypes at Single Cell Resolution.

Authors:  Scott R Kennedy; Eric M Schultz; Thomas M Chappell; Brendan Kohrn; Gary M Knowels; Alan J Herr
Journal:  PLoS Genet       Date:  2015-04-13       Impact factor: 5.917

4.  Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.

Authors:  Artem G Lada; Elena I Stepchenkova; Anna S Zhuk; Sergei F Kliver; Igor B Rogozin; Dmitrii E Polev; Alok Dhar; Youri I Pavlov
Journal:  Front Genet       Date:  2017-12-12       Impact factor: 4.599

5.  Comment on "A commensal strain of Staphylococcus epidermidis protects against skin neoplasia" by Nakatsuji et al.

Authors:  Stanislav G Kozmin; Igor B Rogozin; Elizabeth A Moore; Mariah Abney; Roel M Schaaper; Youri I Pavlov
Journal:  Sci Adv       Date:  2019-09-11       Impact factor: 14.136

6.  Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.

Authors:  Artem G Lada; Elena I Stepchenkova; Irina S R Waisertreiger; Vladimir N Noskov; Alok Dhar; James D Eudy; Robert J Boissy; Masayuki Hirano; Igor B Rogozin; Youri I Pavlov
Journal:  PLoS Genet       Date:  2013-09-05       Impact factor: 5.917
  6 in total

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