| Literature DB >> 30695735 |
Anuradha Sahu1, William Foulsham2, Afsaneh Amouzegar1, Sharad K Mittal1, Sunil K Chauhan3.
Abstract
The therapeutic potential of mesenchymal stem cells (MSCs) has been heralded by their multipotentiality and immunomodulatory capacity. MSCs migrate toward sites of tissue damage, where specific pro-inflammatory factors 'license' their immunosuppressive functions. Recent studies in animal models of ocular surface disease have demonstrated the potential of MSC-derived therapies to limit inflammation and promote tissue repair. Herein, we review the immunoregulatory mechanisms of MSCs, as well as strategies to harness their regenerative function at the cornea. We examine reports of the therapeutic application of MSCs in the setting of ocular surface inflammation; including corneal injury, transplantation, ocular surface autoimmunity and allergy.Entities:
Mesh：
Year: 2019 PMID： 30695735 DOI： 10.1016/j.jtos.2019.01.006
Source DB: PubMed Journal: Ocul Surf ISSN： 1542-0124 Impact factor: 5.033