| Literature DB >> 30695694 |
Leo J Y Kim1, Shruti Bhargava2, Ryan C Gimple1, Jeremy N Rich3.
Abstract
Pediatric tumors have enriched the understanding of germline genotype contribution to tumorigenesis. In this issue of Developmental Cell, Yin et al. (2018) describe genetic models of Sonic Hedgehog (SHH) subgroup of medulloblastoma with SUFU alterations, painting more nuanced roles for SUFU in tumorigenesis and maintenance of Gli2 transcription factor circuitries.Entities:
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Year: 2019 PMID： 30695694 DOI： 10.1016/j.devcel.2019.01.013
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270