Nicolas Goldaracena1, Andrew S Barbas2. 1. Division of Transplant Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia. 2. Division of Abdominal Transplant Surgery, Department of Surgery, Duke University, Durham, North Carolina, USA.
Abstract
PURPOSE OF REVIEW: As experience grows, living donor liver transplantation (LDLT) has become an effective treatment option to overcome the deceased donor organ shortage. RECENT FINDINGS: Donor safety is the highest priority in LDLT. Strict donor selection according to structured protocols and center experience are the main factors that determine donor safety. However, with increased experience, many centers have explored increasing organ availability within living donation by means of ABO incompatible LDLT, dual graft LDLT, and anonymous living donation. Also, this growing experience in LDLT has allowed the transplant community to cautiously explore the role of liver transplantation for hepatocellular carcinoma outside of Milan criteria and patients with unresectable colorectal liver metastases. SUMMARY: LDLT has become established as a viable strategy to ameliorate the organ shortage experienced by centers around the world. Improved understanding of this technique has allowed the improved utilization of live donor graft resources, without compromising donor safety. Moreover, LDLT may offer some advantages over deceased donor liver transplantation and a unique opportunity to assess the broader applicability of liver transplantation.
PURPOSE OF REVIEW: As experience grows, living donor liver transplantation (LDLT) has become an effective treatment option to overcome the deceased donor organ shortage. RECENT FINDINGS:Donor safety is the highest priority in LDLT. Strict donor selection according to structured protocols and center experience are the main factors that determine donor safety. However, with increased experience, many centers have explored increasing organ availability within living donation by means of ABO incompatible LDLT, dual graft LDLT, and anonymous living donation. Also, this growing experience in LDLT has allowed the transplant community to cautiously explore the role of liver transplantation for hepatocellular carcinoma outside of Milan criteria and patients with unresectable colorectal liver metastases. SUMMARY: LDLT has become established as a viable strategy to ameliorate the organ shortage experienced by centers around the world. Improved understanding of this technique has allowed the improved utilization of live donor graft resources, without compromising donor safety. Moreover, LDLT may offer some advantages over deceased donor liver transplantation and a unique opportunity to assess the broader applicability of liver transplantation.
Authors: Eddy P Lincango Naranjo; Estefany Garces-Delgado; Timo Siepmann; Lutz Mirow; Paola Solis-Pazmino; Harold Alexander-Leon; Gabriela Restrepo-Rodas; Rafael Mancero-Montalvo; Cristina J Ponce; Ramiro Cadena-Semanate; Ronnal Vargas-Cordova; Glenda Herrera-Cevallos; Sebastian Vallejo; Carolina Liu-Sanchez; Larry J Prokop; Ioannis A Ziogas; Michail G Vailas; Alfredo D Guerron; Brendan C Visser; Oscar J Ponce; Andrew S Barbas; Dimitrios Moris Journal: J Clin Med Date: 2022-05-05 Impact factor: 4.964
Authors: Christina Dalzell; Paola A Vargas; Kyle Soltys; Frank Dipaola; George Mazariegos; Jose Oberholzer; Nicolas Goldaracena Journal: Transpl Int Date: 2022-03-22 Impact factor: 3.782