| Literature DB >> 30694659 |
Long Ma1, Xiuqi Cao1, Haiyue Wang1, Kui Lu1, Ying Wang1, Chunhao Tu1, Yujie Dai1, Yuanyuan Meng1, Yuyin Li1, Peng Yu1, Shuli Man1, Aipo Diao1.
Abstract
Human flap endonuclease 1 (hFEN1) is instrumental in DNA replication and repair. It is able to cleave the 5' single-stranded protrusion (also known as 5' flap) resulting from strand displacement reactions. In light of its crucial functions, hFEN1 is now deemed as a nontrivial target in the DNA damage response system for anticancer drug development. Herein, we report that myricetin and some natural flavonoids are able to inhibit hFEN1. Structure-activity relationship, inhibitory mechanisms, molecular docking, and cancer cell-based assays have been performed. Our original findings expand the activity of flavonoids and may pave the way for flavonoid-assisted targeted cancer therapy.Entities:
Keywords: colon cancer treatment; flavonoids; human flap endonuclease 1 (hFEN1); inhibitor; molecular docking; myricetin; sensitizing effect; structure−activity relationship analysis
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Year: 2019 PMID： 30694659 DOI： 10.1021/acs.jafc.8b05447
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279