Antti Tiisanoja1, Anna-Maija Syrjälä1,2,3, Miia Tertsonen1, Kaija Komulainen4, Paula Pesonen3,5, Matti Knuuttila1,3, Sirpa Hartikainen6,7, Pekka Ylöstalo1,3. 1. Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland. 2. Dental Training Clinic, Social and Health Services, Oulu, Finland. 3. Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland. 4. Institute of Dentistry, University of Eastern Finland, Kuopio, Finland. 5. Faculty of Medicine, University of Oulu, Oulu, Finland. 6. School of Pharmacy, University of Eastern Finland, Kuopio, Finland. 7. Research Center of Geriatric Care, University of Eastern Finland, Kuopio, Finland.
Abstract
AIM: To study whether dental caries, periodontal disease, and stomatitis, and the related inflammatory burden associate with diagnosed Alzheimer's disease (AD) and dementia among older people. METHODS: The study population included 170 individuals aged ≥75 years. The primary outcome was diagnosed AD and the secondary outcome was any types of diagnosed dementia. Information about participants' oral diseases and the related inflammatory burden was based on the clinical oral examination. Relative risks (RRs) and confidence intervals (CIs) were estimated using regression models. RESULTS: Dental caries, the presence of ≥3 carious teeth (RR: 3.47, 95% CI: 1.09-11.1) and the number of carious teeth (RR: 1.24, CI: 1.11-1.39), and inflammatory burden (RR: 1.44, CI: 1.04-2.01) were associated with a higher likelihood of having AD. Also, periodontal disease and stomatitis were associated, although nonstatistically, with AD and dementia. The risk estimates for any type of dementia were in most cases lower than for AD. CONCLUSION: Oral diseases and the related inflammatory burden were in most cases associated more strongly with diagnosed AD than dementia in general. Of the oral diseases studied, the strongest association was between dental caries and AD.
AIM: To study whether dental caries, periodontal disease, and stomatitis, and the related inflammatory burden associate with diagnosed Alzheimer's disease (AD) and dementia among older people. METHODS: The study population included 170 individuals aged ≥75 years. The primary outcome was diagnosed AD and the secondary outcome was any types of diagnosed dementia. Information about participants' oral diseases and the related inflammatory burden was based on the clinical oral examination. Relative risks (RRs) and confidence intervals (CIs) were estimated using regression models. RESULTS:Dental caries, the presence of ≥3 carious teeth (RR: 3.47, 95% CI: 1.09-11.1) and the number of carious teeth (RR: 1.24, CI: 1.11-1.39), and inflammatory burden (RR: 1.44, CI: 1.04-2.01) were associated with a higher likelihood of having AD. Also, periodontal disease and stomatitis were associated, although nonstatistically, with AD and dementia. The risk estimates for any type of dementia were in most cases lower than for AD. CONCLUSION:Oral diseases and the related inflammatory burden were in most cases associated more strongly with diagnosed AD than dementia in general. Of the oral diseases studied, the strongest association was between dental caries and AD.
Authors: Mario Dioguardi; Giovanni Di Gioia; Giorgia Apollonia Caloro; Giorgia Capocasale; Khrystyna Zhurakivska; Giuseppe Troiano; Lucio Lo Russo; Lorenzo Lo Muzio Journal: Dent J (Basel) Date: 2019-05-01
Authors: Dorina Lauritano; Giulia Moreo; Fedora Della Vella; Dario Di Stasio; Francesco Carinci; Alberta Lucchese; Massimo Petruzzi Journal: Int J Environ Res Public Health Date: 2019-11-18 Impact factor: 3.390
Authors: Haiying Guo; Shuli Chang; Xiaoqin Pi; Fang Hua; Han Jiang; Chang Liu; Minquan Du Journal: Int J Environ Res Public Health Date: 2021-06-25 Impact factor: 3.390