Tian Liu1, Qi Xiong1, Lingling Li1, Yi Hu1. 1. Department of Medical Oncology, Chinese PLA General Hospital, Beijing, China, 100853.
Abstract
AIM: Previous studies showed that some patients after the treatment of anti-programmed cell death protein-1 (anti-PD-1) antibodies experienced immune-related diarrhea. In this study, we aim to explore the association between intestinal microbiota and immune-related diarrhea. METHODS: We obtained the fecal samples of 26 advanced lung cancer patients before the first dose of anti-PD-1 antibodies. RESULTS: Eight of 26 patients experienced diarrhea after the treatment of anti-PD-1 antibodies. At the phylum level, our study demonstrated that Bacteroidetes were higher in diarrhea-free (D-F) patients, while Firmicutes were lower. Bacteroides and Parabacteroides belonging to Bacteroidetes phylum and Phascolarctobacterium of Firmicutes phylum were more abundant in D-F patients. Whereas, Veillonella of Proteobacteria phylum was lower in D-F patients. CONCLUSION: Our study highlights that intestinal microbiota variation is correlated with the subsequent development of immune-related diarrhea.
AIM: Previous studies showed that some patients after the treatment of anti-programmed cell death protein-1 (anti-PD-1) antibodies experienced immune-related diarrhea. In this study, we aim to explore the association between intestinal microbiota and immune-related diarrhea. METHODS: We obtained the fecal samples of 26 advanced lung cancerpatients before the first dose of anti-PD-1 antibodies. RESULTS: Eight of 26 patients experienced diarrhea after the treatment of anti-PD-1 antibodies. At the phylum level, our study demonstrated that Bacteroidetes were higher in diarrhea-free (D-F) patients, while Firmicutes were lower. Bacteroides and Parabacteroides belonging to Bacteroidetes phylum and Phascolarctobacterium of Firmicutes phylum were more abundant in D-F patients. Whereas, Veillonella of Proteobacteria phylum was lower in D-F patients. CONCLUSION: Our study highlights that intestinal microbiota variation is correlated with the subsequent development of immune-related diarrhea.
Authors: Harm Westdorp; Mark W D Sweep; Mark A J Gorris; Frank Hoentjen; Marye J Boers-Sonderen; Rachel S van der Post; Michel M van den Heuvel; Berber Piet; Annemarie Boleij; Haiko J Bloemendal; I Jolanda M de Vries Journal: Front Immunol Date: 2021-10-29 Impact factor: 7.561