| Literature DB >> 30693804 |
Hao Zhang1, Ying Zhang1, Meng-Yue Wang1, Shuo Chen1, Xiao-Bo Li1,2.
Abstract
Phytochemical investigation of Urtica fissa seed led to the isolation of a new secolignan (1) and a new glycoalkaloid (2), together with 16 known compounds (3-18). The subsequent active evaluation indicated that two lignans (1, 12), two ceramides (3, 4), and the glycoalkaloid (2) possessed the significant cytotoxicity. They could obviously inhibit the proliferation of tumor cells HeLa and CCRF-CEM cells, with IC50 values as low as 1.5 μM.Entities:
Keywords: Urtica fissa ; ceramide; cytotoxicity; glycoalkaloid; secolignan; seed
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Year: 2019 PMID： 30693804 DOI： 10.1080/10286020.2018.1563074
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569