Balpreet Singh1, Prakesh S Shah2,3, Jehier Afifi4, C David Simpson4, Souvik Mitra4, Kimberly Dow5, Walid El-Naggar4. 1. Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada. balpreet.singh@iwk.nshealth.ca. 2. Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. 3. Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada. 4. Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada. 5. Department of Pediatrics, Kingston General Hospital, Queen's University, Kingston, ON, Canada.
Abstract
OBJECTIVE: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. STUDY DESIGN: We conducted a retrospective cohort study of infants < 29 weeks' gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. RESULTS: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. CONCLUSION: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.
OBJECTIVE: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. STUDY DESIGN: We conducted a retrospective cohort study of infants < 29 weeks' gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. RESULTS: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. CONCLUSION: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.
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