Andrea F Duncan1, Carla M Bann2, Allison G Dempsey3, Ira Adams-Chapman4, Roy Heyne5, Susan R Hintz6. 1. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. Andrea.F.Duncan@uth.tmc.edu. 2. Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA. 3. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA. 4. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Atlanta, GA, USA. 5. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA. 6. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Stanford University, Palo Alto, CA, USA.
Abstract
OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers. STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses. RESULTS: A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those with CP had hand function abnormalities. CONCLUSIONS: Late CUS findings and severity of WMA were significantly associated with hand function deficits. Hand function deficits were nearly three times more common than CP and may be a useful marker of early brain insult and predictor of preterm birth effects on development.
OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers. STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses. RESULTS: A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those with CP had hand function abnormalities. CONCLUSIONS: Late CUS findings and severity of WMA were significantly associated with hand function deficits. Hand function deficits were nearly three times more common than CP and may be a useful marker of early brain insult and predictor of preterm birth effects on development.
Authors: Fredrik Serenius; Uwe Ewald; Aijaz Farooqi; Vineta Fellman; Maria Hafström; Kerstin Hellgren; Karel Maršál; Andreas Ohlin; Elisabeth Olhager; Karin Stjernqvist; Bo Strömberg; Ulrika Ådén; Karin Källén Journal: JAMA Pediatr Date: 2016-10-01 Impact factor: 16.193
Authors: Susan R Hintz; Patrick D Barnes; Dorothy Bulas; Thomas L Slovis; Neil N Finer; Lisa A Wrage; Abhik Das; Jon E Tyson; David K Stevenson; Waldemar A Carlo; Michele C Walsh; Abbot R Laptook; Bradley A Yoder; Krisa P Van Meurs; Roger G Faix; Wade Rich; Nancy S Newman; Helen Cheng; Roy J Heyne; Betty R Vohr; Michael J Acarregui; Yvonne E Vaucher; Athina Pappas; Myriam Peralta-Carcelen; Deanne E Wilson-Costello; Patricia W Evans; Ricki F Goldstein; Gary J Myers; Brenda B Poindexter; Elisabeth C McGowan; Ira Adams-Chapman; Janell Fuller; Rosemary D Higgins Journal: Pediatrics Date: 2014-12-01 Impact factor: 7.124
Authors: Andrea F Duncan; Carla M Bann; Nathalie L Maitre; Myriam Peralta-Carcelen; Susan R Hintz Journal: J Pediatr Date: 2020-05-28 Impact factor: 4.406