| Literature DB >> 30692610 |
Ravit Hadar1,2, Rebecca Winter2, Henriette Edemann-Callesen1,2,3, Franziska Wieske1, Bettina Habelt1,2, Niranjan Khadka4, Viktoria Felgel-Farnholz2, Elizabeth Barroeta-Hlusicka1,2, Janine Reis5, Cristian Alexandru Tatarau1, Klaus Funke6, Brita Fritsch5, Nadine Bernhardt2, Marom Bikson4, Michael A Nitsche7,8, Christine Winter9,10.
Abstract
Schizophrenia is a severe neurodevelopmental psychiatric affliction manifested behaviorally at late adolescence/early adulthood. Current treatments comprise antipsychotics which act solely symptomatic, are limited in their effectiveness and often associated with side-effects. We here report that application of non-invasive transcranial direct current stimulation (tDCS) during adolescence, prior to schizophrenia-relevant behavioral manifestation, prevents the development of positive symptoms and related neurobiological alterations in the maternal immune stimulation (MIS) model of schizophrenia.Entities:
Mesh：
Year: 2019 PMID： 30692610 DOI： 10.1038/s41380-019-0356-x
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992