Literature DB >> 30692117

Can Mendelian Randomization Shift into Reverse Gear?

Michael V Holmes1,2,3,4, George Davey Smith4,5,6.   

Abstract

Mesh:

Substances:

Year:  2019        PMID: 30692117     DOI: 10.1373/clinchem.2018.296806

Source DB:  PubMed          Journal:  Clin Chem        ISSN: 0009-9147            Impact factor:   8.327


× No keyword cloud information.
  10 in total

1.  Polygenic risk scores and the prediction of common diseases.

Authors:  Mika Ala-Korpela; Michael V Holmes
Journal:  Int J Epidemiol       Date:  2020-02-01       Impact factor: 7.196

2.  Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.

Authors:  Lasse Folkersen; Stefan Gustafsson; Qin Wang; Michael V Holmes; Erik Ingelsson; Anders Mälarstig; Daniel Hvidberg Hansen; Åsa K Hedman; Andrew Schork; Karen Page; Daria V Zhernakova; Yang Wu; James Peters; Niclas Eriksson; Sarah E Bergen; Thibaud S Boutin; Andrew D Bretherick; Stefan Enroth; Anette Kalnapenkis; Jesper R Gådin; Bianca E Suur; Yan Chen; Ljubica Matic; Jeremy D Gale; Julie Lee; Weidong Zhang; Amira Quazi; Mika Ala-Korpela; Seung Hoan Choi; Annique Claringbould; John Danesh; George Davey Smith; Federico de Masi; Sölve Elmståhl; Gunnar Engström; Eric Fauman; Celine Fernandez; Lude Franke; Paul W Franks; Vilmantas Giedraitis; Chris Haley; Anders Hamsten; Andres Ingason; Åsa Johansson; Peter K Joshi; Lars Lind; Cecilia M Lindgren; Steven Lubitz; Tom Palmer; Erin Macdonald-Dunlop; Martin Magnusson; Olle Melander; Karl Michaelsson; Andrew P Morris; Reedik Mägi; Michael W Nagle; Peter M Nilsson; Jan Nilsson; Marju Orho-Melander; Ozren Polasek; Bram Prins; Erik Pålsson; Ting Qi; Marketa Sjögren; Johan Sundström; Praveen Surendran; Urmo Võsa; Thomas Werge; Rasmus Wernersson; Harm-Jan Westra; Jian Yang; Alexandra Zhernakova; Johan Ärnlöv; Jingyuan Fu; J Gustav Smith; Tõnu Esko; Caroline Hayward; Ulf Gyllensten; Mikael Landen; Agneta Siegbahn; James F Wilson; Lars Wallentin; Adam S Butterworth
Journal:  Nat Metab       Date:  2020-10-16

Review 3.  Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.

Authors:  Michael V Holmes; Tom G Richardson; Brian A Ference; Neil M Davies; George Davey Smith
Journal:  Nat Rev Cardiol       Date:  2021-03-11       Impact factor: 32.419

4.  Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.

Authors:  Tom G Richardson; Juha Mykkänen; Katja Pahkala; Mika Ala-Korpela; Joshua A Bell; Kurt Taylor; Jorma Viikari; Terho Lehtimäki; Olli Raitakari; George Davey Smith
Journal:  Int J Epidemiol       Date:  2021-11-10       Impact factor: 7.196

5.  Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases.

Authors:  Scott C Ritchie; Samuel A Lambert; Matthew Arnold; Shu Mei Teo; Sol Lim; Petar Scepanovic; Jonathan Marten; Sohail Zahid; Mark Chaffin; Yingying Liu; Gad Abraham; Willem H Ouwehand; David J Roberts; Nicholas A Watkins; Brian G Drew; Anna C Calkin; Emanuele Di Angelantonio; Nicole Soranzo; Stephen Burgess; Michael Chapman; Sekar Kathiresan; Amit V Khera; John Danesh; Adam S Butterworth; Michael Inouye
Journal:  Nat Metab       Date:  2021-11-08

6.  Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.

Authors:  Tom G Richardson; Genevieve M Leyden; Qin Wang; Joshua A Bell; Benjamin Elsworth; George Davey Smith; Michael V Holmes
Journal:  PLoS Biol       Date:  2022-02-25       Impact factor: 8.029

7.  Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment.

Authors:  Laurence J Howe; Matthew Tudball; George Davey Smith; Neil M Davies
Journal:  Int J Epidemiol       Date:  2022-06-13       Impact factor: 9.685

8.  A multivariant recall-by-genotype study of the metabolomic signature of BMI.

Authors:  Si Fang; Kaitlin H Wade; David A Hughes; Sophie Fitzgibbon; Vikki Yip; Nicholas J Timpson; Laura J Corbin
Journal:  Obesity (Silver Spring)       Date:  2022-05-22       Impact factor: 9.298

9.  Constructing an atlas of associations between polygenic scores from across the human phenome and circulating metabolic biomarkers.

Authors:  Si Fang; Michael V Holmes; Tom R Gaunt; George Davey Smith; Tom G Richardson
Journal:  Elife       Date:  2022-10-11       Impact factor: 8.713

10.  Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis.

Authors:  Tricia M Peters; Michael V Holmes; J Brent Richards; Tom Palmer; Vincenzo Forgetta; Cecilia M Lindgren; Folkert W Asselbergs; Christopher P Nelson; Nilesh J Samani; Mark I McCarthy; Anubha Mahajan; George Davey Smith; Mark Woodward; Linda M O'Keeffe; Sanne A E Peters
Journal:  Diabetes Care       Date:  2020-12-04       Impact factor: 17.152

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.