Rodrigo de Assis Ramos1, Fernando Silva Guimarães1, Yannis Dionyssiotis2, Dorothea Tsekoura3, Jannis Papathanasiou4, Arthur de Sá Ferreira5. 1. Centro Universitário Augusto Motta/UNISUAM, Rio de Janeiro, RJ, Brazil. 2. Physical Medicine & Rehabilitation Department, European Interbalkan Medical Center, Thessaloniki, Greece. 3. Aretaieio Hospital, Athens Medical School, Greece. 4. Department of Medical Imaging, Allergology and Physiotherapy, Faculty of Dental Medicine, Medical University of Plovdiv, Bulgaria; Department of Kinesitherapy, Faculty of Public Health, Medical University of Sofia, Bulgaria. 5. Centro Universitário Augusto Motta/UNISUAM, Rio de Janeiro, RJ, Brazil. Electronic address: arthurde@unisuamdoc.com.br.
Abstract
BACKGROUND: Hypertension is associated with deterioration of musculoskeletal function and functional capacity. Existing prediction models for assessment of the 6-min walk test (6MWT) do not capture the disease-related functional capacity. This study developed a multivariate prediction model of the measured 6-min walked distance (6MWDM) in hypertension and proposed target-values based on optimal therapeutic aims. METHODS: Seventy-six patients (38 men, 56.1 ± 14.3 years, systolic pressure 156.7 ± 17.5 mmHg, diastolic pressure 92.9 ± 6.9 mmHg) underwent anamnesis, physical examination, and laboratory analysis. Functional capacity was assessed using the 6MWT, being the 6MWDM considered as the dependent variable. Independent variables included sex (S, coded 'male' = 1, 'female' = 0), age (A), body height (H), body mass, mean blood pressure (MBP), and physical activity (IPAQ, coded 1-5). Target-values were derived from theoretical scenarios of optimal blood pressure and physical activity, separately and combined. RESULTS: Patients walked 324.5 ± 10.1 m in the average of two trials 30-min apart. Pearson's correlation coefficient showed moderate-to-weak significant associations between 6MWDM and all independent variables. The final multivariate model was 6MWDP = 611.347-4.446 × MBP + 267.630 × H - 1.511 × A + IPAQcode + Scode (adjusted R2 = 0.680, SE of bias = 6.3 m), suggesting that clinical, anthropometric, and hemodynamic information determines functional capacity. Predicted values yielded a group-average of 325 ± 87 m. Target-values under the optimal scenario resulted in 420 ± 60 m. CONCLUSIONS: Sex (men), higher body height, higher physical activity, lower mean blood pressure, and lower age are independently correlated with higher 6MWDM in patients with hypertension. Target-values can be estimated for therapeutic aims related to hemodynamics and lifestyle.
BACKGROUND:Hypertension is associated with deterioration of musculoskeletal function and functional capacity. Existing prediction models for assessment of the 6-min walk test (6MWT) do not capture the disease-related functional capacity. This study developed a multivariate prediction model of the measured 6-min walked distance (6MWDM) in hypertension and proposed target-values based on optimal therapeutic aims. METHODS: Seventy-six patients (38 men, 56.1 ± 14.3 years, systolic pressure 156.7 ± 17.5 mmHg, diastolic pressure 92.9 ± 6.9 mmHg) underwent anamnesis, physical examination, and laboratory analysis. Functional capacity was assessed using the 6MWT, being the 6MWDM considered as the dependent variable. Independent variables included sex (S, coded 'male' = 1, 'female' = 0), age (A), body height (H), body mass, mean blood pressure (MBP), and physical activity (IPAQ, coded 1-5). Target-values were derived from theoretical scenarios of optimal blood pressure and physical activity, separately and combined. RESULTS:Patients walked 324.5 ± 10.1 m in the average of two trials 30-min apart. Pearson's correlation coefficient showed moderate-to-weak significant associations between 6MWDM and all independent variables. The final multivariate model was 6MWDP = 611.347-4.446 × MBP + 267.630 × H - 1.511 × A + IPAQcode + Scode (adjusted R2 = 0.680, SE of bias = 6.3 m), suggesting that clinical, anthropometric, and hemodynamic information determines functional capacity. Predicted values yielded a group-average of 325 ± 87 m. Target-values under the optimal scenario resulted in 420 ± 60 m. CONCLUSIONS: Sex (men), higher body height, higher physical activity, lower mean blood pressure, and lower age are independently correlated with higher 6MWDM in patients with hypertension. Target-values can be estimated for therapeutic aims related to hemodynamics and lifestyle.
Authors: Olga D Lebedeva; Abduahat A Achilov; Zilola F Mavlyanova; Alexey V Baranov; Shachnosa A Achilova; Natalia P Sanina; Anatoly D Fesyun; Andrey P Rachin; Maxim Yu Yakovlev; Kirill V Terentev; Igor V Reverchuk; Alie S Velilyaeva; Maria Chiara Maccarone; Stefano Masiero Journal: Eur J Transl Myol Date: 2021-12-15