Lisa R Maness, Tanya Zubov1.
Abstract
BACKGROUND: Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth.
METHODS: We investigated the effects of 0.5% and 1% concentrations of Rosmarinus officinalis, Cinnamomum verum, Citrus paradisi, and Capsicum annuum extracts on the growth of R. stolonifer and T. mentagrophytes. The combined effects also were determined at 0.5% concentration for these fungal species and for M. gypseum. Fungal species were grown in flasks, along with growth media, for 7, 14, and 21 days, with each species of essential oil or combination of oils and mass determined and compared to its control.
RESULTS: Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi had overall significant inhibitory effects (P ≤.05) on R. stolonifer and T. mentagrophytes. C. annuum significantly (P ≤.05) inhibited the growth of T. mentagrophytes and enhanced that of R. stolonifer. The combination of essential oils resulted in inhibition of growth (P ≤.05) at similar percentages as R. officinalis, C. verum, and C. paradisi only.
CONCLUSION: Essential oils such as Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi may be useful for treating opportunistic and dermatophytic fungal diseases. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
BACKGROUND: Rhizopus stolonifer is an opportunistic fungus that causes respiratory infections, sinusitis, and otomycosis. Trichophyton mentagrophytes and Microsporum gypseum cause athlete's foot, ringworm, and nail infections. Previous research has shown that some essential oils inhibit fungal growth.
METHODS: We investigated the effects of 0.5% and 1% concentrations of Rosmarinus officinalis, Cinnamomum verum, Citrus paradisi, and Capsicum annuum extracts on the growth of R. stolonifer and T. mentagrophytes. The combined effects also were determined at 0.5% concentration for these fungal species and for M. gypseum. Fungal species were grown in flasks, along with growth media, for 7, 14, and 21 days, with each species of essential oil or combination of oils and mass determined and compared to its control.
RESULTS: Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi had overall significant inhibitory effects (P ≤.05) on R. stolonifer and T. mentagrophytes. C. annuum significantly (P ≤.05) inhibited the growth of T. mentagrophytes and enhanced that of R. stolonifer. The combination of essential oils resulted in inhibition of growth (P ≤.05) at similar percentages as R. officinalis, C. verum, and C. paradisi only.
CONCLUSION: Essential oils such as Rosmarinus officinalis, Cinnamomum verum, and Citrus paradisi may be useful for treating opportunistic and dermatophytic fungal diseases. © American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Entities:
Keywords:
zzm321990 Microsporum gypseumzzm321990 ; zzm321990 Rhizopus stoloniferzzm321990 ; zzm321990 Trichophyton mentagrophyteszzm321990 ; dermatophytes; essential oils; opportunistic fungi
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Substances：
Year: 2019
PMID： 30690523 PMCID： PMC6452308 DOI： 10.1093/labmed/lmy080
Source DB: PubMed Journal: Lab Med ISSN： 0007-5027