Marike van der Leeden1, Chloé Balland2, Edwin Geleijn2, Rosalie J Huijsmans2, Joost Dekker3, Marinus A Paul4, Chris Dickhoff5, Martijn M Stuiver6. 1. Department of Rehabilitation Medicine, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands. Electronic address: m.vanderleeden@vumc.nl. 2. Department of Rehabilitation Medicine, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. 3. Department of Rehabilitation Medicine, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, The Netherlands. 4. Department of Cardio-thoracic Surgery, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. 5. Department of Cardio-thoracic Surgery, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Surgery, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. 6. Department of Rehabilitation Medicine, Amsterdam Universitaire Medische Centra (UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; ACHIEVE Center of Applied Research, Faculty of Health, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, University of Amsterdam, The Netherlands.
Abstract
BACKGROUND: Apart from clinical experience and theoretical considerations, there is a lack of evidence that the level of adherence to in-hospital mobilization protocols is related to functional recovery in patients after resection for lung cancer. The objectives of the study were to determine (1) the relationship between adherence to the in-hospital mobilization protocol and physical fitness at hospital discharge and (2) the value of physical fitness measures at discharge in predicting physical functioning 6 weeks and 3 months postoperatively. METHODS: This observational study included 62 patients who underwent surgical resection for lung cancer. Adherence to the in-hospital mobilization protocol was abstracted from patients' records. Physical fitness measures before the operation and at hospital discharge included handgrip strength, 30-second sit-to-stand test, and 6-minute walk test (6MWT). Self-reported physical functioning was assessed preoperatively and 6 weeks and 3 months postoperatively, using the Medical Outcome Study 36-Item Short Form (SF-36) Physical Function subscale (RAND Corp, Santa Monica, CA). Linear regression analyses were used to estimate the relationships of interest, adjusting for potential confounders. RESULTS: Level of adherence to the mobilization protocol was significantly and independently related to handgrip strength, sit-to-stand test, and 6MWT at discharge. Handgrip strength and 6MWT at discharge significantly predicted SF-36 Physical Function at 6 weeks and 3 months postoperatively. The sit-to-stand test only predicted SF-36 Physical Function at 6 weeks. CONCLUSIONS: Suboptimal postoperative mobilization after surgical resection for lung cancer negatively affects physical fitness at discharge. Our results underline the importance of adherence to early postoperative mobilization protocols. Measuring physical fitness at discharge may be useful to inform clinicians on elective referral of patients for postdischarge rehabilitation.
BACKGROUND: Apart from clinical experience and theoretical considerations, there is a lack of evidence that the level of adherence to in-hospital mobilization protocols is related to functional recovery in patients after resection for lung cancer. The objectives of the study were to determine (1) the relationship between adherence to the in-hospital mobilization protocol and physical fitness at hospital discharge and (2) the value of physical fitness measures at discharge in predicting physical functioning 6 weeks and 3 months postoperatively. METHODS: This observational study included 62 patients who underwent surgical resection for lung cancer. Adherence to the in-hospital mobilization protocol was abstracted from patients' records. Physical fitness measures before the operation and at hospital discharge included handgrip strength, 30-second sit-to-stand test, and 6-minute walk test (6MWT). Self-reported physical functioning was assessed preoperatively and 6 weeks and 3 months postoperatively, using the Medical Outcome Study 36-Item Short Form (SF-36) Physical Function subscale (RAND Corp, Santa Monica, CA). Linear regression analyses were used to estimate the relationships of interest, adjusting for potential confounders. RESULTS: Level of adherence to the mobilization protocol was significantly and independently related to handgrip strength, sit-to-stand test, and 6MWT at discharge. Handgrip strength and 6MWT at discharge significantly predicted SF-36 Physical Function at 6 weeks and 3 months postoperatively. The sit-to-stand test only predicted SF-36 Physical Function at 6 weeks. CONCLUSIONS: Suboptimal postoperative mobilization after surgical resection for lung cancer negatively affects physical fitness at discharge. Our results underline the importance of adherence to early postoperative mobilization protocols. Measuring physical fitness at discharge may be useful to inform clinicians on elective referral of patients for postdischarge rehabilitation.
Authors: Marike van der Schaaf; Marike van der Leeden; Marijke E de Leeuwerk; Petra Bor; Hidde P van der Ploeg; Vincent de Groot Journal: Int J Behav Nutr Phys Act Date: 2022-05-23 Impact factor: 8.915
Authors: Marijke Elizabeth de Leeuwerk; Martine Botjes; Vincent van Vliet; Edwin Geleijn; Vincent de Groot; Erwin van Wegen; Marike van der Schaaf; Jurriaan Tuynman; Chris Dickhoff; Marike van der Leeden Journal: JMIR Cancer Date: 2022-06-24
Authors: Joske Nauta; Femke van Nassau; Adrie J Bouma; Leonie A Krops; Hidde P van der Ploeg; Evert Verhagen; Lucas H V van der Woude; Helco G van Keeken; L M Buffart; Ron Diercks; Vincent de Groot; Johan de Jong; Caroline Kampshoff; Martin Stevens; Inge van den Akker-Scheek; Marike van der Leeden; Willem van Mechelen; Rienk Dekker Journal: BMJ Open Date: 2022-03-15 Impact factor: 2.692
Authors: Adrie Bouma; Femke van Nassau; Joske Nauta; Leonie Krops; Hidde van der Ploeg; Evert Verhagen; Lucas van der Woude; Helco van Keeken; Rienk Dekker Journal: BMC Med Inform Decis Mak Date: 2022-09-22 Impact factor: 3.298