Itai Ghersin1,2, Neron Khteeb1, Lior H Katz3,4, Saleh Daher1, Raanan Shamir4,5, Amit Assa4,5. 1. Israel Defense Forces, Medical Corps, Ramat Gan, Israel. 2. Department of Internal Medicine, Rambam Health Care Campus, Haifa, Israel. 3. Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel. 4. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 5. Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Abstract
BACKGROUND: The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries. AIM: To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents METHODS: The files of the army medical corps were reviewed for adolescents recruited in 2002-2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Findings were compared with the remaining recruits without IBD. RESULTS: Of the 1,144,213 adolescents recruited, 2372 (0.2%) had IBD (Crohn's disease, 68%). Median age of the cohort was 17.1 years (interquartile range, 16.9-17.3). Over the study period, the annual point prevalence per 100,000 examinees significantly increased: total IBD, 58 to 373; Crohn's disease, 42 to 425; ulcerative colitis, 16 to 128. Mean age at IBD diagnosis decreased from 15.0 ± 2.8 years in 2002-2008 to 14.3 ± 3.1 years in 2009-2016 (P < 0.0001). Significance was maintained on separate analyses of Crohn's disease and ulcerative colitis. Both diseases were significantly less prevalent in subjects from families with at least one parent born in a developing country and ≥3 children. There was a significant association of lower socioeconomic status with lower prevalence of Crohn's disease (odds ratio 0.41, 95% confidence interval, 0.31-0.54) and ulcerative colitis (odds ratio 0.25, 95% confidence interval, 0.15-0.42). CONCLUSIONS: The point prevalence of Crohn's disease and ulcerative colitis in Israeli Jewish adolescents increased six-fold and eight-fold, respectively, over 15 years along with a decrease in age at diagnosis.
BACKGROUND: The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries. AIM: To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents METHODS: The files of the army medical corps were reviewed for adolescents recruited in 2002-2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Findings were compared with the remaining recruits without IBD. RESULTS: Of the 1,144,213 adolescents recruited, 2372 (0.2%) had IBD (Crohn's disease, 68%). Median age of the cohort was 17.1 years (interquartile range, 16.9-17.3). Over the study period, the annual point prevalence per 100,000 examinees significantly increased: total IBD, 58 to 373; Crohn's disease, 42 to 425; ulcerative colitis, 16 to 128. Mean age at IBD diagnosis decreased from 15.0 ± 2.8 years in 2002-2008 to 14.3 ± 3.1 years in 2009-2016 (P < 0.0001). Significance was maintained on separate analyses of Crohn's disease and ulcerative colitis. Both diseases were significantly less prevalent in subjects from families with at least one parent born in a developing country and ≥3 children. There was a significant association of lower socioeconomic status with lower prevalence of Crohn's disease (odds ratio 0.41, 95% confidence interval, 0.31-0.54) and ulcerative colitis (odds ratio 0.25, 95% confidence interval, 0.15-0.42). CONCLUSIONS: The point prevalence of Crohn's disease and ulcerative colitis in Israeli Jewish adolescents increased six-fold and eight-fold, respectively, over 15 years along with a decrease in age at diagnosis.
Authors: Ben Kang; Jung Eun Kim; Jae Hun Jung; Jae Young Choe; Mi Jin Kim; Yon Ho Choe; Seung Kim; Hong Koh; Yoo Min Lee; Jee Hyun Lee; Yoon Lee; Ji-Hyuk Lee; Hae Jeong Lee; Hyo-Jeong Jang; Youjin Choi; So Yoon Choi; Ju Young Kim; Byung-Ho Choe Journal: Pediatr Gastroenterol Hepatol Nutr Date: 2020-01-09
Authors: Manasi Agrawal; João Sabino; Catarina Frias-Gomes; Christen M Hillenbrand; Celine Soudant; Jordan E Axelrad; Shailja C Shah; Francisco Ribeiro-Mourão; Thomas Lambin; Inga Peter; Jean-Frederic Colombel; Neeraj Narula; Joana Torres Journal: EClinicalMedicine Date: 2021-05-15
Authors: Jae Young Choe; Sujin Choi; Ki Hwan Song; Hyo-Jeong Jang; Kwang-Hae Choi; Dae Yong Yi; Suk Jin Hong; Jun Hyun Hwang; Seung-Man Cho; Young Jin Kim; Byung-Ho Choe; Ben Kang Journal: Front Pediatr Date: 2022-01-04 Impact factor: 3.418