Tomofumi Miura1,2, Yoshihisa Matsumoto1, Takashi Kawaguchi3, Yuto Masuda4, Ayumi Okizaki1, Hiroko Koga1, Keita Tagami5, Yuki Sumazaki Watanabe1, Yuko Uehara1, Takuhiro Yamaguchi6, Tatsuya Morita7. 1. a Department of Palliative Medicine , National Cancer Center Hospital East , Kashiwa , Japan. 2. b Division of Biomarker Discovery , Exploratory Oncology Research & Clinical Trial Center, National Cancer Center , Kashiwa , Japan. 3. c Department of Practical Pharmacy , Tokyo University of Pharmacy and Life Sciences , Hachioji , Japan. 4. d Japanese Red Cross Koga Hospital , Koga , Japan. 5. e Department of Palliative Medicine , Tohoku University , Sendai , Japan. 6. f Division of Biostatistics , Tohoku University Graduate School of Medicine , Sendai , Japan. 7. g Palliative and Supportive Care Division , Seirei Mikatahara Hospital , Hamamatsu , Japan.
Abstract
OBJECTIVES: Phase angle (PA) is a poor prognostic factor in patients with advanced cancer. This study aimed to identify possible correlations between PA and symptoms, quality of life, fluid retention, and laboratory data in cancer patients in palliative care settings. METHODS: Individuals who visited the outpatient clinic or were admitted to the palliative care unit were eligible. Patients with a performance status of 4 and/or those unable to complete questionnaires were excluded. PA was evaluated using a bioanalyzer device. The correlation coefficient between PA and the variables of interest was analyzed. RESULTS: A total of 102 patients were analyzed. PA was weakly correlated with age (ρ = -0.22), performance status (ρ = -0.30), functional well-being (ρ = 0.20), anorexia/cachexia subscale (ρ = 0.22), and Functional Assessment of Anorexia/Cachexia Therapy trial outcome index (ρ = 0.26). PA was also correlated with fluid retention (ρ = -0.34) and albumin (ρ = 0.32), C-reactive protein (ρ = -0.31), and hemoglobin (ρ = 0.41) levels. Sub-analysis stratified according to sex revealed that males demonstrated the same results; however, female sex demonstrated a correlation between PA and social well-being (ρ = -0.43). CONCLUSIONS: PA was correlated with physical condition, but not with psychological well-being.
OBJECTIVES: Phase angle (PA) is a poor prognostic factor in patients with advanced cancer. This study aimed to identify possible correlations between PA and symptoms, quality of life, fluid retention, and laboratory data in cancerpatients in palliative care settings. METHODS: Individuals who visited the outpatient clinic or were admitted to the palliative care unit were eligible. Patients with a performance status of 4 and/or those unable to complete questionnaires were excluded. PA was evaluated using a bioanalyzer device. The correlation coefficient between PA and the variables of interest was analyzed. RESULTS: A total of 102 patients were analyzed. PA was weakly correlated with age (ρ = -0.22), performance status (ρ = -0.30), functional well-being (ρ = 0.20), anorexia/cachexia subscale (ρ = 0.22), and Functional Assessment of Anorexia/Cachexia Therapy trial outcome index (ρ = 0.26). PA was also correlated with fluid retention (ρ = -0.34) and albumin (ρ = 0.32), C-reactive protein (ρ = -0.31), and hemoglobin (ρ = 0.41) levels. Sub-analysis stratified according to sex revealed that males demonstrated the same results; however, female sex demonstrated a correlation between PA and social well-being (ρ = -0.43). CONCLUSIONS: PA was correlated with physical condition, but not with psychological well-being.
Authors: Tatyanne L N Gomes; Jéssika D P Soares; Thaís C Borges; Claude Pichard; Gustavo D Pimentel Journal: Eur J Clin Nutr Date: 2020-03-02 Impact factor: 4.016
Authors: Rúben Francisco; Catarina L Nunes; João Breda; Filipe Jesus; Henry Lukaski; Luís B Sardinha; Analiza M Silva Journal: Biology (Basel) Date: 2022-06-10