Nancy E Lane1. 1. Center for Musculoskeletal Health, University of California at Davis Health System, 4625 Second Avenue, Suite 2006, Sacramento, CA, 95817, USA. nelane@ucdavis.edu.
Abstract
PURPOSE OF THIS REVIEW: The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS: Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together may explain the greater reductions in bone strength than those of bone mass. Treatments with parathyroid hormone fragments appear to reverse glucocorticoid-induced bone loss and fracture risk partially through maintaining bone vascularity and bone strength. This review identifies how glucocorticoid anti-osteogenic and vascular effects together may reduce bone strength. It also provides guidance to clinicians on rationale treatment for glucocorticoid-induced osteoporosis.
PURPOSE OF THIS REVIEW: The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations. RECENT FINDINGS: Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together may explain the greater reductions in bone strength than those of bone mass. Treatments with parathyroid hormone fragments appear to reverse glucocorticoid-induced bone loss and fracture risk partially through maintaining bone vascularity and bone strength. This review identifies how glucocorticoid anti-osteogenic and vascular effects together may reduce bone strength. It also provides guidance to clinicians on rationale treatment for glucocorticoid-induced osteoporosis.
Entities:
Keywords:
Bone cells; Bone vascularity; Glucocorticoids; Osteonecrosis; Parathyroid hormone
Authors: Junjing Jia; Wei Yao; Min Guan; Weiwei Dai; Mohammad Shahnazari; Rekha Kar; Lynda Bonewald; Jean X Jiang; Nancy E Lane Journal: FASEB J Date: 2011-06-24 Impact factor: 5.191
Authors: S Wallach; S Cohen; D M Reid; R A Hughes; D J Hosking; R F Laan; S M Doherty; M Maricic; C Rosen; J Brown; I Barton; A A Chines Journal: Calcif Tissue Int Date: 2000-10 Impact factor: 4.333
Authors: Kenneth G Saag; Elizabeth Shane; Steven Boonen; Fernando Marín; David W Donley; Kathleen A Taylor; Gail P Dalsky; Robert Marcus Journal: N Engl J Med Date: 2007-11-15 Impact factor: 91.245
Authors: Wei Yao; Zhiqiang Cheng; Aaron Pham; Cheryl Busse; Elizabeth A Zimmermann; Robert O Ritchie; Nancy E Lane Journal: Arthritis Rheum Date: 2008-11
Authors: David M Reid; Jean-Pierre Devogelaer; Kenneth Saag; Christian Roux; Chak-Sing Lau; Jean-Yves Reginster; Philemon Papanastasiou; Alberto Ferreira; Florian Hartl; Taiwo Fashola; Peter Mesenbrink; Philip N Sambrook Journal: Lancet Date: 2009-04-11 Impact factor: 79.321
Authors: Robert S Weinstein; Chao Wan; Qinglan Liu; Ying Wang; Maria Almeida; Charles A O'Brien; Jeff Thostenson; Paula K Roberson; Adele L Boskey; Thomas L Clemens; Stavros C Manolagas Journal: Aging Cell Date: 2009-12-28 Impact factor: 9.304
Authors: Osvaldo D Messina; Luis Fernando Vidal; Maritza Vidal Vidal; Irene E M Bultink; Hennie G Raterman; William Lems Journal: Aging Clin Exp Res Date: 2021-03-22 Impact factor: 3.636
Authors: Shuman Yang; Na Wang; Jianmeng Wang; Lisa M Lix; William D Leslie; Baoming Yuan Journal: Arch Osteoporos Date: 2022-08-12 Impact factor: 2.879