Elysia M Davis1, Cheryl L Hubley-Kozey2, Scott C Landry3, Dianne M Ikeda4, William D Stanish5, Janie L Astephen Wilson6. 1. School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada. Electronic address: elysia.davis@dal.ca. 2. School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada; School of Physiotherapy, Dalhousie University, 5869 University Avenue, Halifax, NS B3H 4R2, Canada. 3. School of Kinesiology, Acadia University, 550 Main Street Wolfville, Nova Scotia B4P 2R6, Canada; School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada. 4. School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada. 5. School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada; Department of Surgery, Division of Orthopaedics, Dalhousie University, 1278 Tower Road Halifax, NS B3H 2Y9, Canada. 6. School of Biomedical Engineering, Dalhousie University, 5981 University Ave, Halifax, NS B3H 1W2, Canada; Department of Surgery, Division of Orthopaedics, Dalhousie University, 1278 Tower Road Halifax, NS B3H 2Y9, Canada; Department of Surgery, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada.
Abstract
BACKGROUND: It is currently not known if there are different mechanical factors involved in accelerated rates of knee osteoarthritis structural progression. Data regarding the role of the transverse plane moment along with the contributions to joint loading from muscle activity, a primary contributor to the joint loading environment, is not well represented in the current literature on knee OA radiographic progression. The objective of this study was to understand if a 3-year end point corroborates what has been shown for longer term radiographic progression or provides more insight into factors that may be implicated in more accelerated radiographic progression than those shown previously. METHODS: 52 participants visited the Dynamics of Human Motion laboratory at baseline for three-dimensional, self-selected speed over ground walking gait analysis. Differences in magnitude and patterns of 3D knee moments and electromyography waveforms between participants who progressed radiographically from those that did not were compared using t-tests (P < 0.05). FINDINGS: Features of the frontal and transverse plane knee moments along with muscle activation patterns for the lateral gastrocnemius and lateral hamstrings differentiated the progression group from the non-progression group at baseline. INTERPRETATION: In general, the walking gait biomechanics of the progression group in this 3-year radiographic study aligned well with previously reported characteristics of diagnosed or symptomatic osteoarthritis. The higher rotation moment range during stance found with the progression group is a novel finding that points to a need to better understand torsional joint loading and its implications for loading of the knee joint tissues.
BACKGROUND: It is currently not known if there are different mechanical factors involved in accelerated rates of knee osteoarthritis structural progression. Data regarding the role of the transverse plane moment along with the contributions to joint loading from muscle activity, a primary contributor to the joint loading environment, is not well represented in the current literature on knee OA radiographic progression. The objective of this study was to understand if a 3-year end point corroborates what has been shown for longer term radiographic progression or provides more insight into factors that may be implicated in more accelerated radiographic progression than those shown previously. METHODS: 52 participants visited the Dynamics of Human Motion laboratory at baseline for three-dimensional, self-selected speed over ground walking gait analysis. Differences in magnitude and patterns of 3D knee moments and electromyography waveforms between participants who progressed radiographically from those that did not were compared using t-tests (P < 0.05). FINDINGS: Features of the frontal and transverse plane knee moments along with muscle activation patterns for the lateral gastrocnemius and lateral hamstrings differentiated the progression group from the non-progression group at baseline. INTERPRETATION: In general, the walking gait biomechanics of the progression group in this 3-year radiographic study aligned well with previously reported characteristics of diagnosed or symptomatic osteoarthritis. The higher rotation moment range during stance found with the progression group is a novel finding that points to a need to better understand torsional joint loading and its implications for loading of the knee joint tissues.
Authors: M T Murphy; N Wang; D T Felson; M C Nevitt; C E Lewis; L Frey-Law; A Guermazi; N A Segal Journal: Osteoarthritis Cartilage Date: 2022-03-18 Impact factor: 7.507