Winsley Rose1, Kulandaipalayam Natarajan Sindhu2, Asha Mary Abraham3, Gagandeep Kang4, Jacob John5. 1. Department of Child Health, Christian Medical College, Vellore, Tamil Nadu 632004, India. Electronic address: winsleyrose@cmcvellore.ac.in. 2. The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India. Electronic address: sindhukn@cmcvellore.ac.in. 3. Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu 632004, India. Electronic address: asha_ma@cmcvellore.ac.in. 4. The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu 632004, India. Electronic address: gkang@cmcvellore.ac.in. 5. Department of Community Health, Christian Medical College, Vellore, Tamil Nadu 632004, India. Electronic address: jacob@cmcsph.org.
Abstract
OBJECTIVES: Our main objective was to estimate population based dengue incidence estimates in children with fever >3 days. METHODS: The study used the 'National Surveillance System for Enteric Fever in India' (NSSEFI) cohort at the Vellore site. Children aged 6 months to 14 years from a peri-urban setting in Vellore were followed up for a year for the presence of fever. All children who had fever >3days were eligible for blood culture to diagnose typhoid. All children that presented with fever >3days on alternate days of the week were also tested for dengue. Dengue incidence estimates were then calculated. RESULTS: There were 6648 children followed up with a cumulative observation period of 5800 child years. There were 11753 fever episodes with 3171 (27%) episodes lasting >3 days. Totally, 784 children with 868 episodes of fever were tested for Dengue. NS1 antigen or Dengue IgM or both were positive in 82 (9.4%) of those tested for Dengue. Dengue PCR was positive in 33/64 (51.6%) of the samples positive samples. The annual incidence rate of dengue was 49.5 per 1000 child years among children with fever >3 days. CONCLUSIONS: There is high burden of dengue in peri-urban Vellore.
OBJECTIVES: Our main objective was to estimate population based dengue incidence estimates in children with fever >3 days. METHODS: The study used the 'National Surveillance System for Enteric Fever in India' (NSSEFI) cohort at the Vellore site. Children aged 6 months to 14 years from a peri-urban setting in Vellore were followed up for a year for the presence of fever. All children who had fever >3days were eligible for blood culture to diagnose typhoid. All children that presented with fever >3days on alternate days of the week were also tested for dengue. Dengue incidence estimates were then calculated. RESULTS: There were 6648 children followed up with a cumulative observation period of 5800 child years. There were 11753 fever episodes with 3171 (27%) episodes lasting >3 days. Totally, 784 children with 868 episodes of fever were tested for Dengue. NS1 antigen or Dengue IgM or both were positive in 82 (9.4%) of those tested for Dengue. Dengue PCR was positive in 33/64 (51.6%) of the samples positive samples. The annual incidence rate of dengue was 49.5 per 1000 child years among children with fever >3 days. CONCLUSIONS: There is high burden of dengue in peri-urban Vellore.
Authors: K Alagarasu; J A Patil; M B Kakade; A M More; M Bote; D Chowdhury; M Seervi; N T Rajesh; M Ashok; B Anukumar; A M Abraham; D Parashar; P S Shah Journal: Infect Genet Evol Date: 2019-07-31 Impact factor: 3.342
Authors: Kevin John John; Karthik Gunasekaran; John Davis Prasad; Divya Mathew; Sohini Das; N Sultan; Asha Mary Abraham; Ramya Iyyadurai Journal: Interdiscip Perspect Infect Dis Date: 2019-09-04
Authors: Oliver Mendoza-Cano; Pedro Rincón-Avalos; Verity Watson; Abdou Khouakhi; Jesús López-de la Cruz; Angelica Patricia Ruiz-Montero; Cynthia Monique Nava-Garibaldi; Mario Lopez-Rojas; Efrén Murillo-Zamora Journal: Int J Environ Res Public Health Date: 2021-04-16 Impact factor: 3.390