Kald Beshir Tuem1, Rahel Desta1, Helen Bitew2, Seid Ibrahim3, Hailemichael Zeru Hishe4. 1. Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia. 2. Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. 3. Clinical Pharmacy Unit, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. 4. Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, Mekelle University, P.O. Box 1871, Mekelle, Ethiopia. Electronic address: hailemichael.zeru@mu.edu.et.
Abstract
OBJECTIVES: Urinary tract infections (UTIs) are one of the most common infections in humans. Studies have shown that antibiotics for UTIs are usually prescribed empirically before the results of urine culture are available. The aim of the study was to assess the antimicrobial resistance patterns of bacteria isolated from urine samples over 6 years in Ayder Comprehensive Specialized Hospital (ACSH), in Mekelle, Northern Ethiopia. METHODS: A retrospective study of culture results of UTI samples was conducted in ACSH from January 2012 to December 2017. Data were collected using a structured data sheet format and were analysed using SPSS v.20.0. RESULTS: Among 1080 urine samples tested during the 6-year period, 308 (28.5%) were positive for bacterial isolates. The majority of participants were female (57.8%). The three most commonly isolated bacteria were Escherichia coli (48.1%), Klebsiella pneumoniae (16.2%) and Pseudomonas aeruginosa (6.5%). Escherichia coli was found to be most susceptible to imipenem (100%) and most resistant to ampicillin (94.9%). Similarly, K. pneumoniae was sensitive to meropenem (100%) but resistant to penicillin (100%). Multidrug resistance to two or more antimicrobials was observed in 267 isolates (86.7%), with a non-significantly higher prevalence in females (χ2=9.65, P=0.29). The overall pooled bacterial resistance was 57.8%. CONCLUSION: This study revealed that most of the urine isolates showed high levels of antimicrobial resistance to commonly prescribed antibiotics although they remained susceptible to imipenem, nitrofurantoin and meropenem. The results call for continuous surveillance of antimicrobial resistance for better management of patients with UTIs.
OBJECTIVES:Urinary tract infections (UTIs) are one of the most common infections in humans. Studies have shown that antibiotics for UTIs are usually prescribed empirically before the results of urine culture are available. The aim of the study was to assess the antimicrobial resistance patterns of bacteria isolated from urine samples over 6 years in Ayder Comprehensive Specialized Hospital (ACSH), in Mekelle, Northern Ethiopia. METHODS: A retrospective study of culture results of UTI samples was conducted in ACSH from January 2012 to December 2017. Data were collected using a structured data sheet format and were analysed using SPSS v.20.0. RESULTS: Among 1080 urine samples tested during the 6-year period, 308 (28.5%) were positive for bacterial isolates. The majority of participants were female (57.8%). The three most commonly isolated bacteria were Escherichia coli (48.1%), Klebsiella pneumoniae (16.2%) and Pseudomonas aeruginosa (6.5%). Escherichia coli was found to be most susceptible to imipenem (100%) and most resistant to ampicillin (94.9%). Similarly, K. pneumoniae was sensitive to meropenem (100%) but resistant to penicillin (100%). Multidrug resistance to two or more antimicrobials was observed in 267 isolates (86.7%), with a non-significantly higher prevalence in females (χ2=9.65, P=0.29). The overall pooled bacterial resistance was 57.8%. CONCLUSION: This study revealed that most of the urine isolates showed high levels of antimicrobial resistance to commonly prescribed antibiotics although they remained susceptible to imipenem, nitrofurantoin and meropenem. The results call for continuous surveillance of antimicrobial resistance for better management of patients with UTIs.
Authors: Julian S O Campbell; Saskia van Henten; Zikan Koroma; Ibrahim Franklyn Kamara; Gladys N Kamara; Hemant Deepak Shewade; Anthony D Harries Journal: Int J Environ Res Public Health Date: 2022-04-16 Impact factor: 4.614
Authors: Domingo Palacios-Ceña; Lidiane Lima Florencio; Valentín Hernández-Barrera; Cesar Fernandez-de-Las-Peñas; Javier de Miguel-Diez; David Martínez-Hernández; David Carabantes-Alarcón; Rodrigo Jimenez-García; Ana Lopez-de-Andres; Marta Lopez-Herranz Journal: J Clin Med Date: 2021-05-26 Impact factor: 4.241