Anaïs Potron1, Maxime Bour2, Pauline Triponney2, Joris Muller3, Christelle Koebel4, Rémy A Bonnin5, Patrick Plésiat6. 1. Centre National de Référence de la résistance aux antibiotiques, Centre Hospitalier Universitaire de Besançon, France; UMR6249 CNRS Chrono-Environnement, Université de Franche-Comté, Besançon, France. Electronic address: anais.potron@univ-fcomte.fr. 2. Centre National de Référence de la résistance aux antibiotiques, Centre Hospitalier Universitaire de Besançon, France. 3. Laboratoire d'Hygiène, Centre Hospitalier Universitaire de Strasbourg, France. 4. Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Strasbourg, France. 5. EA7361 'Structure, dynamique, fonction et expression des β-lactamases à large spectre', Université Paris-Sud, LabEx Lermit, Faculté de Médecine, Le Kremlin-Bicêtre, France; Centre National de Référence de la résistance aux antibiotiques, laboratoire associé, Le Kremlin-Bicêtre, France. 6. Centre National de Référence de la résistance aux antibiotiques, Centre Hospitalier Universitaire de Besançon, France; UMR6249 CNRS Chrono-Environnement, Université de Franche-Comté, Besançon, France.
Abstract
OBJECTIVES: This study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii). METHODS AND RESULTS: The isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the international clonal complex CC2. One of these isolates sequentially developed a high resistance to colistin and rifampicin under treatment, as a result of mutations in genes pmrB and rpoB, respectively. The blaOXA-72 gene was localised on a 10-kb transferable plasmid, named pAB-STR-1, whose sequence is nearly identical to that of another plasmid previously found in Lithuanian strains, pAB120. CONCLUSION: This report highlighted the need to carefully monitor the emergence of colistin and rifampicin resistance in patients treated for infections with multidrug-resistant A. baumannii.
OBJECTIVES: This study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii). METHODS AND RESULTS: The isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the international clonal complex CC2. One of these isolates sequentially developed a high resistance to colistin and rifampicin under treatment, as a result of mutations in genes pmrB and rpoB, respectively. The blaOXA-72 gene was localised on a 10-kb transferable plasmid, named pAB-STR-1, whose sequence is nearly identical to that of another plasmid previously found in Lithuanian strains, pAB120. CONCLUSION: This report highlighted the need to carefully monitor the emergence of colistin and rifampicin resistance in patients treated for infections with multidrug-resistant A. baumannii.
Authors: András Fodor; Birhan Addisie Abate; Péter Deák; László Fodor; Ervin Gyenge; Michael G Klein; Zsuzsanna Koncz; Josephat Muvevi; László Ötvös; Gyöngyi Székely; Dávid Vozik; László Makrai Journal: Pathogens Date: 2020-06-29
Authors: Yasmine H Tartor; Norhan K Abd El-Aziz; Rasha M A Gharieb; Hend M El Damaty; Shymaa Enany; Enas A Soliman; Samah S Abdellatif; Amira S A Attia; Mosa M Bahnass; Yousry A El-Shazly; Mohammed Elbediwi; Hazem Ramadan Journal: Front Microbiol Date: 2021-12-08 Impact factor: 5.640