Nam Hee Kim1, Yoon Suk Jung2, Jae Wan Lim2, Jung Ho Park2, Dong Il Park2, Chong Il Sohn2. 1. Preventive Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. 2. Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
BACKGROUND AND AIMS: A fecal immunochemical test (FIT) is often repeated annually, even after a recent colonoscopy. However, there are no published data on the proper approach to FIT-positive patients after a recent colonoscopy. We compared colorectal cancer (CRC) and advanced colorectal neoplasia (ACRN) prevalence based on the interval since the last colonoscopy. METHODS: We reviewed asymptomatic screenees aged ≥50 years who underwent FIT and colonoscopy. RESULTS: Of 2228 FIT-positive participants, 514 had a colonoscopy less than 3 years before (group 1), 427 had a colonoscopy had a colonoscopy 3 to 10 years before (group 2), and 1287 had a colonoscopy >10 years before or no colonoscopy (group 3). The prevalence of CRC in groups 1, 2, and 3 was 2.1%, 1.6%, and 7.2%, respectively, and that for ACRN was 10.9%, 12.6%, and 26.0%, respectively. Even after adjusting for confounders, CRC and ACRN detection rates in group 1 were lower than those in group 3 but not lower than those in group 2. Among 6135 FIT-negative participants, the prevalence of CRC in the 3 groups was .7%, .4%, and 3.4%, respectively, and that for ACRN was 6.0%, 6.1%, and 14.7%, respectively. CRC and ACRN detection rates were significantly higher in FIT-positive participants than in FIT-negative participants in all 3 groups. CONCLUSIONS: In FIT-positive patients who underwent colonoscopy within the prior 3 years, CRC and ACRN prevalence was not low. Our findings support the U.S. Multi-Society Task Force on the CRC screening recommendation that repeat colonoscopy be offered to patients with positive FIT results and recent colonoscopy.
BACKGROUND AND AIMS: A fecal immunochemical test (FIT) is often repeated annually, even after a recent colonoscopy. However, there are no published data on the proper approach to FIT-positive patients after a recent colonoscopy. We compared colorectal cancer (CRC) and advanced colorectal neoplasia (ACRN) prevalence based on the interval since the last colonoscopy. METHODS: We reviewed asymptomatic screenees aged ≥50 years who underwent FIT and colonoscopy. RESULTS: Of 2228 FIT-positive participants, 514 had a colonoscopy less than 3 years before (group 1), 427 had a colonoscopy had a colonoscopy 3 to 10 years before (group 2), and 1287 had a colonoscopy >10 years before or no colonoscopy (group 3). The prevalence of CRC in groups 1, 2, and 3 was 2.1%, 1.6%, and 7.2%, respectively, and that for ACRN was 10.9%, 12.6%, and 26.0%, respectively. Even after adjusting for confounders, CRC and ACRN detection rates in group 1 were lower than those in group 3 but not lower than those in group 2. Among 6135 FIT-negative participants, the prevalence of CRC in the 3 groups was .7%, .4%, and 3.4%, respectively, and that for ACRN was 6.0%, 6.1%, and 14.7%, respectively. CRC and ACRN detection rates were significantly higher in FIT-positive participants than in FIT-negative participants in all 3 groups. CONCLUSIONS: In FIT-positive patients who underwent colonoscopy within the prior 3 years, CRC and ACRN prevalence was not low. Our findings support the U.S. Multi-Society Task Force on the CRC screening recommendation that repeat colonoscopy be offered to patients with positive FIT results and recent colonoscopy.
Authors: Vivy T Cusumano; Anthony Myint; Edgar Corona; Liu Yang; Jennifer Bocek; Antonio G Lopez; Marcela Zhou Huang; Naveen Raja; Anna Dermenchyan; Lily Roh; Maria Han; Daniel Croymans; Folasade P May Journal: Dig Dis Sci Date: 2021-02-20 Impact factor: 3.199
Authors: Vivy T Cusumano; Edgar Corona; Diana Partida; Liu Yang; Christine Yu; Folasade P May Journal: BMC Gastroenterol Date: 2020-04-19 Impact factor: 3.067
Authors: Derek W Ebner; Jason D Eckmann; Kelli N Burger; Douglas W Mahoney; Jamie Bering; Allon Kahn; Eduardo A Rodriguez; David O Prichard; Michael B Wallace; Sunanda V Kane; Lila J Finney Rutten; Suryakanth R Gurudu; John B Kisiel Journal: Clin Transl Gastroenterol Date: 2021-06-18 Impact factor: 4.488