Xiaochun Xiao1, Hedong Han1, Cheng Wu1, Qian He1, Yiming Ruan1, Yinghong Zhai2, Yongqing Gao2, Xinxin Zhao2, Jia He3. 1. Department of Health Statistics, Second Military Medical University, Shanghai, China. 2. Tongji University School of Medicine, Shanghai, China. 3. Department of Health Statistics, Second Military Medical University, Shanghai, China; Tongji University School of Medicine, Shanghai, China. Electronic address: hejia63@yeah.net.
Abstract
BACKGROUND: This study aimed to evaluate the prevalence of atrial fibrillation (AF) in hospital encounters with end-stage COPD on home oxygen admitted for COPD exacerbation. METHODS: We used the 2003 to 2014 Nationwide Inpatient Sample to conduct a retrospective analysis. This study included all patients ≥ 18 years of age with a primary diagnosis of COPD on home oxygen who were hospitalized for COPD exacerbation. We used multivariate-adjusted models to evaluate the association of AF with clinical factors, cost, length of stay, and hospital outcomes. RESULTS: In total, 1,345,270 patients were included; of these, 244,488 (18.2%) had AF. The AF prevalence increased from 12.9% in 2003 to 21.3% in 2014 (P < .0001) and varied by age, sex, race, income, insurance type, and hospital region. Advancing age, female sex, white race, high income, and large hospital size were associated with increased odds of AF. Presence of AF was a risk predictor for in-hospital death (OR, 1.54; 95% CI, 1.45-1.65), acute respiratory failure (OR, 1.09; 95% CI, 1.06-1.12), invasive mechanical ventilation (OR, 1.37; 95% CI, 1.29-1.47), noninvasive mechanical ventilation (OR, 1.14; 95% CI, 1.09-1.18), acute kidney injury (OR, 1.09; 95% CI, 1.04-1.13), sepsis (OR, 1.23; 95% CI, 1.10-1.37), and stroke (OR, 1.80; 95% CI, 1.40-2.32). AF was also associated with increased cost and length of stay. CONCLUSIONS: AF prevalence in hospital encounters with end-stage COPD increased from 2003 to 2014. Better management strategies for patients with end-stage COPD comorbid with AF are needed, especially in elderly individuals.
BACKGROUND: This study aimed to evaluate the prevalence of atrial fibrillation (AF) in hospital encounters with end-stage COPD on home oxygen admitted for COPD exacerbation. METHODS: We used the 2003 to 2014 Nationwide Inpatient Sample to conduct a retrospective analysis. This study included all patients ≥ 18 years of age with a primary diagnosis of COPD on home oxygen who were hospitalized for COPD exacerbation. We used multivariate-adjusted models to evaluate the association of AF with clinical factors, cost, length of stay, and hospital outcomes. RESULTS: In total, 1,345,270 patients were included; of these, 244,488 (18.2%) had AF. The AF prevalence increased from 12.9% in 2003 to 21.3% in 2014 (P < .0001) and varied by age, sex, race, income, insurance type, and hospital region. Advancing age, female sex, white race, high income, and large hospital size were associated with increased odds of AF. Presence of AF was a risk predictor for in-hospital death (OR, 1.54; 95% CI, 1.45-1.65), acute respiratory failure (OR, 1.09; 95% CI, 1.06-1.12), invasive mechanical ventilation (OR, 1.37; 95% CI, 1.29-1.47), noninvasive mechanical ventilation (OR, 1.14; 95% CI, 1.09-1.18), acute kidney injury (OR, 1.09; 95% CI, 1.04-1.13), sepsis (OR, 1.23; 95% CI, 1.10-1.37), and stroke (OR, 1.80; 95% CI, 1.40-2.32). AF was also associated with increased cost and length of stay. CONCLUSIONS:AF prevalence in hospital encounters with end-stage COPD increased from 2003 to 2014. Better management strategies for patients with end-stage COPD comorbid with AF are needed, especially in elderly individuals.
Authors: Morohunfolu Akinnusi; Abdul Rahman El-Masri; Yolanda Lawson; Ali Albert El-Solh Journal: Intern Emerg Med Date: 2020-08-17 Impact factor: 3.397