Taeang Arai1, Masanori Atsukawa2, Akihito Tsubota3, Mai Koeda1, Yuji Yoshida1, Tomomi Okubo1, Ai Nakagawa4, Norio Itokawa1, Chisa Kondo4, Katsuhisa Nakatsuka4, Takushi Masu4, Keizo Kato5, Noritomo Shimada6, Tsutomu Hatori7, Naoya Emoto8, Masayoshi Kage9, Katsuhiko Iwakiri4. 1. Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan. 2. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. Electronic address: momogachi@yahoo.co.jp. 3. Core Research Facilities for Basic Science, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan. 4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. 5. Department of Gastroenterology and Hepatology, Department of Internal Medicine, Shinmatsudo Central General Hospital, Matsudo, Chiba, Japan. 6. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Otakanomori Hospital, Kashiwa, Chiba, Japan. 7. Division of Pathology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan. 8. Division of Endocrinology, Department of Internal Medicine, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan. 9. Molecular Targeting Therapeutics Division, Research Center for Innovative Cancer Therapy, Kurume University, Fukuoka, Japan.
Abstract
BACKGROUND: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. AIMS: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. METHODS: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. RESULTS: In this study, vitamin D deficiency defined as 25-hydroxyvitamin-D3 levels of ≤20 ng/mL was found in 151 patients (65.9%). Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1 rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Old age (p = 5.05 × 10-8), high body mass index (p = 2.13 × 10-2), low total-cholesterol (p = 1.46 × 10-4), low serum vitamin D level (p = 7.34 × 10-3), and VDR rs1544410 genotype CC (p = 9.15 × 10-3) were independent factors associated with advanced liver fibrosis. CONCLUSION: Serum 25-hydroxyvitamin-D3 levels and the VDR gene SNP were significantly and independently associated with the severity of liver fibrosis in patients with biopsy-proven NAFLD.
BACKGROUND:Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear. AIMS: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD. METHODS: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. RESULTS: In this study, vitamin D deficiency defined as 25-hydroxyvitamin-D3 levels of ≤20 ng/mL was found in 151 patients (65.9%). Multivariate analysis revealed that cold season, advanced fibrosis, and CYP2R1rs1993116 genotype non-AA were independent factors significantly associated with vitamin D deficiency. Old age (p = 5.05 × 10-8), high body mass index (p = 2.13 × 10-2), low total-cholesterol (p = 1.46 × 10-4), low serum vitamin D level (p = 7.34 × 10-3), and VDRrs1544410 genotype CC (p = 9.15 × 10-3) were independent factors associated with advanced liver fibrosis. CONCLUSION: Serum 25-hydroxyvitamin-D3 levels and the VDR gene SNP were significantly and independently associated with the severity of liver fibrosis in patients with biopsy-proven NAFLD.
Authors: Pierre-Christian Violet; Ifechukwude C Ebenuwa; Yu Wang; Mahtab Niyyati; Sebastian J Padayatty; Brian Head; Kenneth Wilkins; Stacey Chung; Varsha Thakur; Lynn Ulatowski; Jeffrey Atkinson; Mikel Ghelfi; Sheila Smith; Hongbin Tu; Gerd Bobe; Chia-Ying Liu; David W Herion; Robert D Shamburek; Danny Manor; Maret G Traber; Mark Levine Journal: JCI Insight Date: 2020-01-16
Authors: Siarhei A Dabravolski; Evgeny E Bezsonov; Mirza S Baig; Tatyana V Popkova; Ludmila V Nedosugova; Antonina V Starodubova; Alexander N Orekhov Journal: Int J Mol Sci Date: 2021-04-24 Impact factor: 5.923
Authors: Tae Hyung Kim; Seung Gyu Yun; Jimi Choi; Hyun Gil Goh; Han Ah Lee; Sun Young Yim; Seong Ji Choi; Young Sun Lee; Eileen L Yoon; Young Kul Jung; Yeon Seok Seo; Ji Hoon Kim; Hyung Joon Yim; Jong Eun Yeon; Kwan Soo Byun; Soon Ho Um Journal: J Korean Med Sci Date: 2020-05-18 Impact factor: 2.153