Literature DB >> 30683265

Germline and Somatic Tumor Testing in Gynecologic Cancer Care.

Jill Alldredge1, Leslie Randall2.   

Abstract

New technologies have advanced the science of tumor biology and genomics. Commercially available germline and somatic testing modalities have the downstream benefits of enabling prevention strategies in women with hereditary cancers and their family members in addition to identifying women who benefit most from novel targeted therapeutics. The matrix of available testing is complex and evolving. Women's health providers need to be versed in benefits and limitations of available testing. Genetic counselors play a pivotal role in interpretation of relevant mutations, and in avoiding common pitfalls, but their skill set is not sufficient to optimally integrate cancer genomics into clinical practice.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Genomics; Germline; Gynecologic cancer; Somatic; Tumor testing

Mesh:

Year:  2019        PMID: 30683265      PMCID: PMC7480763          DOI: 10.1016/j.ogc.2018.09.003

Source DB:  PubMed          Journal:  Obstet Gynecol Clin North Am        ISSN: 0889-8545            Impact factor:   2.844


  36 in total

1.  A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.

Authors:  Ashton C Berger; Anil Korkut; Rupa S Kanchi; Apurva M Hegde; Walter Lenoir; Wenbin Liu; Yuexin Liu; Huihui Fan; Hui Shen; Visweswaran Ravikumar; Arvind Rao; Andre Schultz; Xubin Li; Pavel Sumazin; Cecilia Williams; Pieter Mestdagh; Preethi H Gunaratne; Christina Yau; Reanne Bowlby; A Gordon Robertson; Daniel G Tiezzi; Chen Wang; Andrew D Cherniack; Andrew K Godwin; Nicole M Kuderer; Janet S Rader; Rosemary E Zuna; Anil K Sood; Alexander J Lazar; Akinyemi I Ojesina; Clement Adebamowo; Sally N Adebamowo; Keith A Baggerly; Ting-Wen Chen; Hua-Sheng Chiu; Steve Lefever; Liang Liu; Karen MacKenzie; Sandra Orsulic; Jason Roszik; Carl Simon Shelley; Qianqian Song; Christopher P Vellano; Nicolas Wentzensen; John N Weinstein; Gordon B Mills; Douglas A Levine; Rehan Akbani
Journal:  Cancer Cell       Date:  2018-04-02       Impact factor: 31.743

2.  BRCA mutations and risk of uterine cancer.

Authors:  Sanjay Tanday
Journal:  Lancet Oncol       Date:  2016-07-07       Impact factor: 41.316

Review 3.  Lynch Syndrome Screening in the Gynecologic Tract: Current State of the Art.

Authors:  Anne M Mills; Teri A Longacre
Journal:  Am J Surg Pathol       Date:  2016-04       Impact factor: 6.394

4.  Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study.

Authors:  Nicoletta Resta; Daniela Pierannunzio; Gennaro Mariano Lenato; Alessandro Stella; Riccardo Capocaccia; Rosanna Bagnulo; Patrizia Lastella; Francesco Claudio Susca; Cristina Bozzao; Daria Carmela Loconte; Carlo Sabbà; Emanuele Urso; Paola Sala; Mara Fornasarig; Paola Grammatico; Ada Piepoli; Cristina Host; Daniela Turchetti; Alessandra Viel; Luigi Memo; Laura Giunti; Vittoria Stigliano; Liliana Varesco; Lucio Bertario; Maurizio Genuardi; Emanuela Lucci Cordisco; Maria Grazia Tibiletti; Carmela Di Gregorio; Angelo Andriulli; Maurizio Ponz de Leon
Journal:  Dig Liver Dis       Date:  2013-02-15       Impact factor: 4.088

5.  Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry.

Authors:  Kris Ann P Schultz; M Cristina Pacheco; Jiandong Yang; Gretchen M Williams; Yoav Messinger; D Ashley Hill; Louis P Dehner; John R Priest
Journal:  Gynecol Oncol       Date:  2011-04-17       Impact factor: 5.482

6.  Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.

Authors:  Asad Umar; C Richard Boland; Jonathan P Terdiman; Sapna Syngal; Albert de la Chapelle; Josef Rüschoff; Richard Fishel; Noralane M Lindor; Lawrence J Burgart; Richard Hamelin; Stanley R Hamilton; Robert A Hiatt; Jeremy Jass; Annika Lindblom; Henry T Lynch; Païvi Peltomaki; Scott D Ramsey; Miguel A Rodriguez-Bigas; Hans F A Vasen; Ernest T Hawk; J Carl Barrett; Andrew N Freedman; Sudhir Srivastava
Journal:  J Natl Cancer Inst       Date:  2004-02-18       Impact factor: 13.506

Review 7.  POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance.

Authors:  Fernando Bellido; Marta Pineda; Gemma Aiza; Rafael Valdés-Mas; Matilde Navarro; Diana A Puente; Tirso Pons; Sara González; Silvia Iglesias; Esther Darder; Virginia Piñol; José Luís Soto; Alfonso Valencia; Ignacio Blanco; Miguel Urioste; Joan Brunet; Conxi Lázaro; Gabriel Capellá; Xose S Puente; Laura Valle
Journal:  Genet Med       Date:  2015-07-02       Impact factor: 8.822

8.  Integrated genomic and molecular characterization of cervical cancer.

Authors: 
Journal:  Nature       Date:  2017-01-23       Impact factor: 49.962

9.  Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Authors:  Claire Palles; Jean-Baptiste Cazier; Kimberley M Howarth; Enric Domingo; Angela M Jones; Peter Broderick; Zoe Kemp; Sarah L Spain; Estrella Guarino; Estrella Guarino Almeida; Israel Salguero; Amy Sherborne; Daniel Chubb; Luis G Carvajal-Carmona; Yusanne Ma; Kulvinder Kaur; Sara Dobbins; Ella Barclay; Maggie Gorman; Lynn Martin; Michal B Kovac; Sean Humphray; Anneke Lucassen; Christopher C Holmes; David Bentley; Peter Donnelly; Jenny Taylor; Christos Petridis; Rebecca Roylance; Elinor J Sawyer; David J Kerr; Susan Clark; Jonathan Grimes; Stephen E Kearsey; Huw J W Thomas; Gilean McVean; Richard S Houlston; Ian Tomlinson
Journal:  Nat Genet       Date:  2012-12-23       Impact factor: 38.330

10.  Integrated genomic characterization of endometrial carcinoma.

Authors:  Cyriac Kandoth; Nikolaus Schultz; Andrew D Cherniack; Rehan Akbani; Yuexin Liu; Hui Shen; A Gordon Robertson; Itai Pashtan; Ronglai Shen; Christopher C Benz; Christina Yau; Peter W Laird; Li Ding; Wei Zhang; Gordon B Mills; Raju Kucherlapati; Elaine R Mardis; Douglas A Levine
Journal:  Nature       Date:  2013-05-02       Impact factor: 49.962

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  2 in total

1.  Germline Testing for Patients With BRCA1/2 Mutations on Somatic Tumor Testing.

Authors:  Katherine Vlessis; Natasha Purington; Nicolette Chun; Sigurdis Haraldsdottir; James M Ford
Journal:  JNCI Cancer Spectr       Date:  2019-11-11

Review 2.  Homologous recombination proficiency in ovarian and breast cancer patients.

Authors:  Justin Fortune Creeden; Nisha S Nanavaty; Katelyn R Einloth; Cassidy E Gillman; Laura Stanbery; Danae M Hamouda; Lance Dworkin; John Nemunaitis
Journal:  BMC Cancer       Date:  2021-10-28       Impact factor: 4.430

  2 in total

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