Literature DB >> 30681673

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury.

Fei Yan1, Xiangge Tian, Zhilin Luan, Lei Feng, Xiaochi Ma, Tony D James.   

Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-d-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

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Year:  2019        PMID: 30681673     DOI: 10.1039/c8cc10311a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

Review 1.  Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases.

Authors:  Jiaguo Huang; Kanyi Pu
Journal:  Chem Sci       Date:  2020-06-18       Impact factor: 9.825

  1 in total

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