Christos Chouaid1, Nicola Germain2, Gérard De Pouvourville3, Samuel Aballéa2, Daria Korchagina2, Michael Baldwin4, Katell Le Lay5, Laura Luciani5, Mondher Toumi6, Philippe Devillier7. 1. a Pneumology , CHIC Creteil , Creteil , France. 2. b Health Economics and Outcomes Research , Creativ-Ceutical , Paris , France. 3. c Chair of Health Systems , ESSEC Business School , Cergy Pontoise , France. 4. d TA Respiratory/Biosimilars , Boehringer Ingelheim , Ingelheim am Rhein , Germany. 5. e Boehringer Ingelheim , Paris , France. 6. f Public Health , Aix-Marseille Université, Jardin du Pharo , Marseille , France. 7. g UPRES EA 220, Université Paris Saclay , Hôpital Foch , Suresnes , France.
Abstract
OBJECTIVES: Understanding inhaler preferences may contribute to improving adherence in COPD patients and improving long-term outcomes. This study aims to identify and quantify preferences for convenience-related inhaler attributes in French moderate-to-severe COPD patients, with discrete choice experiment (DCE) methodology. METHODS: Attributes were defined from a literature search, clinician and patient interviews: shape, dose insertion, dose preparation, dose release, dose confirmation, dose counter and reusability. An online DCE was conducted in respondents with self-reported COPD stage 2-4 recruited through a panel. The study questionnaire included twelve choice scenarios per respondent and questions on patient characteristics, treatment and disease severity. Statistical analyses used a mixed logit regression model with random effects. Utility scores were estimated for four types of inhalers: Inhaler A - soft mist inhaler; Inhaler B - reusable soft mist inhaler; Inhaler C - multi-dose dry powder inhaler; and Inhaler D - single dose dry powder inhaler. RESULTS: The study was completed by 153 patients (50 females); respondents were 50.4 years old on average; 13 different inhaler devices were reported. The most preferred inhaler is L-shaped, has dose preparation with capsule insertion and a dose counter, and is reusable. Inhaler profiles A and B had the highest utilities (mean of 1.2533 and 0.9578 respectively) compared to inhaler C (0.6315) and D (0.2200). CONCLUSIONS: This study showed statistically significant results that the strongest drivers of preference in French users of inhalation devices for COPD are shape, dose counter and reusability. Convenience-related characteristics are important to patients and should be taken into account by clinicians prescribing these devices.
OBJECTIVES: Understanding inhaler preferences may contribute to improving adherence in COPDpatients and improving long-term outcomes. This study aims to identify and quantify preferences for convenience-related inhaler attributes in French moderate-to-severe COPDpatients, with discrete choice experiment (DCE) methodology. METHODS: Attributes were defined from a literature search, clinician and patient interviews: shape, dose insertion, dose preparation, dose release, dose confirmation, dose counter and reusability. An online DCE was conducted in respondents with self-reported COPD stage 2-4 recruited through a panel. The study questionnaire included twelve choice scenarios per respondent and questions on patient characteristics, treatment and disease severity. Statistical analyses used a mixed logit regression model with random effects. Utility scores were estimated for four types of inhalers: Inhaler A - soft mist inhaler; Inhaler B - reusable soft mist inhaler; Inhaler C - multi-dose dry powder inhaler; and Inhaler D - single dose dry powder inhaler. RESULTS: The study was completed by 153 patients (50 females); respondents were 50.4 years old on average; 13 different inhaler devices were reported. The most preferred inhaler is L-shaped, has dose preparation with capsule insertion and a dose counter, and is reusable. Inhaler profiles A and B had the highest utilities (mean of 1.2533 and 0.9578 respectively) compared to inhaler C (0.6315) and D (0.2200). CONCLUSIONS: This study showed statistically significant results that the strongest drivers of preference in French users of inhalation devices for COPD are shape, dose counter and reusability. Convenience-related characteristics are important to patients and should be taken into account by clinicians prescribing these devices.
Authors: Nigel S Cook; Gerard J Criner; Pierre-Régis Burgel; Katie Mycock; Tom Gardner; Phil Mellor; Pam Hallworth; Kate Sully; Sophi Tatlock; Beyza Klein; Byron Jones; Olivier Le Rouzic; Kip Adams; Kirsten Phillips; Mike McKevitt; Kazuko Toyama; Florian S Gutzwiller Journal: ERJ Open Res Date: 2022-06-13