Dilek Solmaz1, Sibel Bakirci1, Gezmis Kimyon2, Esen K Gunal3, Atalay Dogru4, Ozun Bayindir5, Ediz Dalkilic6, Cem Ozisler7, Meryem Can8, Servet Akar9, Gozde Y Cetin10, Sule Yavuz8, Levent Kilic11, Emine F Tarhan12, Orhan Kucuksahin13, Ahmet Omma14, Emel Gonullu15, Fatih Yildiz16, Emine D Ersozlu17, Muhammet Cinar18, Atallah Al-Onazi1, Abdulsamet Erden11, Muge A Tufan19, Sema Yilmaz20, Seval Pehlevan21, Umut Kalyoncu11, Sibel Z Aydin1. 1. University of Ottawa, Ottawa, Ontario, Canada. 2. Mustafa Kemal University, Hatay, Turkey. 3. Medeniyet University Goztepe Education and Research Hospital, Istanbul, Turkey. 4. Suleyman Demirel University, Isparta, Turkey. 5. Ege University, Izmir, Turkey. 6. Uludag University, Bursa, Turkey. 7. Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. 8. Marmara University, Istanbul, Turkey. 9. Izmir Katip Celebi University, Izmir, Turkey. 10. Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. 11. Hacettepe University, Ankara, Turkey. 12. Mugla Sitki Kocman University, Turkey. 13. Ankara Yildirim Beyazit University, Ankara, Turkey. 14. Ankara Numune Education and Research Hospital, Ankara, Turkey. 15. Eskisehir Osmangazi University, Eskisehir, Turkey. 16. Van Education and Research Hospital, Van, Turkey. 17. Adana Numune Education and Research Hospital, Adana, Turkey. 18. Gulhane School Of Medicine, Ankara, Turkey. 19. Gazi University, Ankara, Turkey. 20. Selcuk University, Konya, Turkey. 21. Fatih University, Istanbul, Turkey.
Abstract
OBJECTIVE: Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. METHODS: Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. RESULTS: A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR 1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR 0.417) and higher risk of deformities (OR 2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR 2.143) and lower risk of plaque psoriasis (OR 0.324). CONCLUSION: Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.
OBJECTIVE:Psoriatic arthritis (PsA) has a genetic background. Approximately 40% of patients with psoriasis or PsA have a family history of psoriasis or PsA, which may affect disease features. The aim of this study was to assess the effects of family history of psoriasis and PsA on disease phenotypes. METHODS: Data from 1,393 patients recruited in the longitudinal, multicenter Psoriatic Arthritis International Database were analyzed. The effects of family history of psoriasis and/or PsA on characteristics of psoriasis and PsA were investigated using logistic regression. RESULTS: A total of 444 patients (31.9%) had a family history of psoriasis and/or PsA. These patients were more frequently women, had earlier onset of psoriasis, more frequent nail disease, enthesitis, and deformities, and less frequently achieved minimal disease activity. Among 444 patients, 335 only had psoriasis in their family, 74 had PsA, and 35 patients were not certain about having PsA and psoriasis in their family, so they were excluded from further analysis. In the multivariate analysis, family history of psoriasis was associated with younger age at onset of psoriasis (odds ratio [OR] 0.976) and presence of enthesitis (OR 1.931), whereas family history of PsA was associated with lower risk of plaque psoriasis (OR 0.417) and higher risk of deformities (OR 2.557). Family history of PsA versus psoriasis showed increased risk of deformities (OR 2.143) and lower risk of plaque psoriasis (OR 0.324). CONCLUSION: Family history of psoriasis and PsA impacts skin phenotypes, musculoskeletal features, and disease severity. The link between family history of psoriasis/PsA and pustular/plaque phenotypes may point to a different genetic background and pathogenic mechanisms in these subsets.