Hadis Mozaffari1, Elnaz Daneshzad1, Bagher Larijani2, Nick Bellissimo3, Leila Azadbakht4,5. 1. Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, P. O. Box: 1416643931, Tehran, Iran. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 3. School of Nutrition, Ryerson University, Toronto, Canada. 4. Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, P. O. Box: 1416643931, Tehran, Iran. azadbakhtleila@gmail.com. 5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. azadbakhtleila@gmail.com.
Abstract
PURPOSE: Fish consumption and dietary intake of n-3 polyunsaturated acids (PUFAs) may be associated with inflammatory bowel disease (IBD). We aimed to conduct a systematic review and summarize published articles on the association between fish consumption and dietary intake of n-3 PUFAs with the risk of IBD. METHODS: PubMed, Scopus, and Web of Science databases were used to conduct a comprehensive search and identify eligible literature published prior to January 2019. Fixed-effects model or random-effects models (DerSimonian-Laird method) were applied to pool the effect sizes. Cochrane Q test was used to trace the potential source of heterogeneity across studies. RESULTS: 12 studies (5 prospective and 7 case-control) were included in the systematic review, which ten of them were eligible for inclusion in the meta-analysis. Studies were included a total sample size of 282610 participants which 2002 of them were cases of IBD [1061 Crohn's disease (CD) and 937 ulcerative colitis (UC)]. A negative association was found between fish consumption and the incidence of CD (pooled effect size: 0.54, 95%CI: 0.31-0.96, P = 0.03). There was no relationship between total dietary n-3 PUFAs intake and IBD (pooled effect size: 1.17, 95%CI: 0.80-1.72, P = 0.41). A significant inverse association was observed between dietary long-chain n-3 PUFAs and the risk of UC (pooled effect size: 0.75, 95%CI: 0.57-0.98, P = 0.03). Moreover, no association was found between α-Linolenic acid (ALA) and IBD (pooled effect size: 1.17, 95%CI: 0.63-2.17, P = 0.62). CONCLUSIONS: Findings showed a negative association between fish consumption and the risk of CD. Moreover, there was a significant inverse association between dietary long-chain n-3 PUFAs and the risk of UC.
PURPOSE: Fish consumption and dietary intake of n-3 polyunsaturated acids (PUFAs) may be associated with inflammatory bowel disease (IBD). We aimed to conduct a systematic review and summarize published articles on the association between fish consumption and dietary intake of n-3 PUFAs with the risk of IBD. METHODS: PubMed, Scopus, and Web of Science databases were used to conduct a comprehensive search and identify eligible literature published prior to January 2019. Fixed-effects model or random-effects models (DerSimonian-Laird method) were applied to pool the effect sizes. Cochrane Q test was used to trace the potential source of heterogeneity across studies. RESULTS: 12 studies (5 prospective and 7 case-control) were included in the systematic review, which ten of them were eligible for inclusion in the meta-analysis. Studies were included a total sample size of 282610 participants which 2002 of them were cases of IBD [1061 Crohn's disease (CD) and 937 ulcerative colitis (UC)]. A negative association was found between fish consumption and the incidence of CD (pooled effect size: 0.54, 95%CI: 0.31-0.96, P = 0.03). There was no relationship between total dietary n-3 PUFAs intake and IBD (pooled effect size: 1.17, 95%CI: 0.80-1.72, P = 0.41). A significant inverse association was observed between dietary long-chain n-3 PUFAs and the risk of UC (pooled effect size: 0.75, 95%CI: 0.57-0.98, P = 0.03). Moreover, no association was found between α-Linolenic acid (ALA) and IBD (pooled effect size: 1.17, 95%CI: 0.63-2.17, P = 0.62). CONCLUSIONS: Findings showed a negative association between fish consumption and the risk of CD. Moreover, there was a significant inverse association between dietary long-chain n-3 PUFAs and the risk of UC.
Authors: Ibrahim Abubakar; Deborah J Myhill; Andrew R Hart; Iain R Lake; Ian Harvey; Jonathan M Rhodes; Richard Robinson; Alan J Lobo; Christopher S J Probert; Paul R Hunter Journal: Am J Epidemiol Date: 2007-01-19 Impact factor: 4.897
Authors: Konstantinos Gkikas; Konstantinos Gerasimidis; Simon Milling; Umer Z Ijaz; Richard Hansen; Richard K Russell Journal: Nutrients Date: 2020-07-07 Impact factor: 5.717
Authors: Dennis R Warner; Jeffrey B Warner; Josiah E Hardesty; Ying L Song; Taylor N King; Jing X Kang; Chih-Yu Chen; Shanfu Xie; Fang Yuan; Md Aminul Islam Prodhan; Xipeng Ma; Xiang Zhang; Eric C Rouchka; Krishna Rao Maddipati; Joan Whitlock; Eric C Li; Gary P Wang; Craig J McClain; Irina A Kirpich Journal: J Lipid Res Date: 2019-10-04 Impact factor: 5.922