Peng-Tao Ma1, Ning-Ning Wu, Rong Pei. 1. Department of Stomatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital. Zhengzhou 450053, China. E-mail:1300469652@qq.com.
Abstract
PURPOSE: To study the effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer (ROU) and on immunological regulation. METHODS: This randomized controlled clinical study prospectively enrolled 204 patients with ROU who were randomly divided into 2 groups. Patients in group A received Garlicin Capsules 1/time, 3 times/d, combined with Kangfuxin liquid 10 mL to gargle 3 times/d; patients in group B only received Kangfuxin liquid 10 mL gargle 5 min, 3/d. The treatment lasted for 2 weeks. The curative effect was compared before and after treatment, including ulcer surface pain (VAS score), time of ulcer healing, and the changes of T cell subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) before and after treatment were compared by SPSS 22 software package. RESULTS: Ulcer healing time (3.5±0.6) d, duration of pain (3.1±0.3)d in group A were shorter than in group B (P<0.05); treatment efficiency was 96.08% in group A, 88.24% in group B( χ2=6.264, P<0.05). The pain scores of both groups were significantly reduced after treatment, and the difference was significant between group A and group B [(1.1±0.4) vs (3.2± 0.6)] (P<0.05). The levels of CD3+, CD4+, CD4+/CD8+ in group A were significantly higher than those in group A after treatment (P<0.05), the levels of CD8+ was significant lower than in group B (P<0.05). CONSLUSIONS: Kangfuxin liquid combined with Garlicin Capsules can improve the therapeutic effect of ROU and repair of local damaged mucosa in children, increasing the immune function of children.
PURPOSE: To study the effect of Kangfuxin liquid combined with Garlicin Capsules in treatment of children with recurrent oral ulcer (ROU) and on immunological regulation. METHODS: This randomized controlled clinical study prospectively enrolled 204 patients with ROU who were randomly divided into 2 groups. Patients in group A received Garlicin Capsules 1/time, 3 times/d, combined with Kangfuxin liquid 10 mL to gargle 3 times/d; patients in group B only received Kangfuxin liquid 10 mL gargle 5 min, 3/d. The treatment lasted for 2 weeks. The curative effect was compared before and after treatment, including ulcer surface pain (VAS score), time of ulcer healing, and the changes of T cell subsets (CD3+, CD4+, CD8+ and CD4+/CD8+) before and after treatment were compared by SPSS 22 software package. RESULTS: Ulcer healing time (3.5±0.6) d, duration of pain (3.1±0.3)d in group A were shorter than in group B (P<0.05); treatment efficiency was 96.08% in group A, 88.24% in group B( χ2=6.264, P<0.05). The pain scores of both groups were significantly reduced after treatment, and the difference was significant between group A and group B [(1.1±0.4) vs (3.2± 0.6)] (P<0.05). The levels of CD3+, CD4+, CD4+/CD8+ in group A were significantly higher than those in group A after treatment (P<0.05), the levels of CD8+ was significant lower than in group B (P<0.05). CONSLUSIONS: Kangfuxin liquid combined with Garlicin Capsules can improve the therapeutic effect of ROU and repair of local damaged mucosa in children, increasing the immune function of children.