| Literature DB >> 30679875 |
Ashok Sharma1,2, Maria L Valle1, Connor Beveridge1, Yutao Liu1,3, Shruti Sharma4,5.
Abstract
Diabetic retinopathy (DR) is a microvascular disease of the retina and the leading cause of visual disability in diabetic patients. Genetic factors have shown to play a pivotal role in DR onset, and several candidate genes have been associated with its progression. A literature search was performed to identify the genes known to be associated with DR through linkage analysis, candidate gene association, and genome-wide association studies (GWAS). A further literature search was performed to discover their potential connection with various biological pathways. A total of 65 genes were found and several of these genes belong to major signaling pathways known to play a significant role in DR, including systemic inflammation, angiogenesis, and neurogenesis. A comprehensive analysis presented in this review will be helpful in unraveling the role of genetics in the pathogenesis of DR.Entities:
Mesh：
Year: 2019 PMID： 30679875 PMCID： PMC6461978 DOI： 10.1038/s41433-019-0337-y
Source DB: PubMed Journal: Eye (Lond) ISSN： 0950-222X Impact factor: 3.775