Literature DB >> 30676761

Palladium-Promoted DNA-Compatible Heck Reaction.

Xuan Wang1,2, Hui Sun1, Jiaxiang Liu1, Wenge Zhong2, Mingqiang Zhang2, Hu Zhou1, Dongcheng Dai2, Xiaojie Lu1.   

Abstract

Optimal conditions for palladium-promoted Heck reaction on DNA were developed with good to excellent conversions. Versatility with either DNA-conjugated styrene/acrylamide or aryl iodide and a broad substrate scope of the corresponding coupling partners were established. Furthermore, robustness of the Heck reaction conditions on single-strand DNA and feasibility for DNA-encoded library production were demonstrated.

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Year:  2019        PMID： 30676761     DOI： 10.1021/acs.orglett.8b03926

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis.

Authors:  Anokha S Ratnayake; Mark E Flanagan; Timothy L Foley; Justin D Smith; Jillian G Johnson; Justin Bellenger; Justin I Montgomery; Brian M Paegel
Journal:  ACS Comb Sci       Date:  2019-09-06       Impact factor: 3.784

2.  Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis.

Authors:  Jian-Yuan Li; Gabriella Miklossy; Ram K Modukuri; Kurt M Bohren; Zhifeng Yu; Murugesan Palaniappan; John C Faver; Kevin Riehle; Martin M Matzuk; Nicholas Simmons
Journal:  Bioconjug Chem       Date:  2019-07-31       Impact factor: 4.774

3.  Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering.

Authors:  Ke Li; Xiaohong Liu; Sixiu Liu; Yulong An; Yanfang Shen; Qingxia Sun; Xiaodong Shi; Wenji Su; Weiren Cui; Zhiqiang Duan; Letian Kuai; Hongfang Yang; Alexander L Satz; Kaixian Chen; Hualiang Jiang; Mingyue Zheng; Xuanjia Peng; Xiaojie Lu
Journal:  iScience       Date:  2020-05-07

Review 4.  DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output.

Authors:  Ying Shi; Yan-Ran Wu; Jian-Qiang Yu; Wan-Nian Zhang; Chun-Lin Zhuang
Journal:  RSC Adv       Date:  2021-01-19       Impact factor: 3.361

5.  In-solution direct oxidative coupling for the integration of sulfur/selenium into DNA-encoded chemical libraries.

Authors:  Shilian Yang; Guixian Zhao; Yuting Gao; Yang Sun; Gong Zhang; Xiaohong Fan; Yangfeng Li; Yizhou Li
Journal:  Chem Sci       Date:  2022-02-01       Impact factor: 9.825

6.  Metal-Free and Open-Air Arylation Reactions of Diaryliodonium Salts for DNA-Encoded Library Synthesis.

Authors:  Hongtao Xu; Tingting Tan; Yiyuan Zhang; Yan Wang; Kangyin Pan; Ying Yao; Shuning Zhang; Yuang Gu; Wanting Chen; Jie Li; Hewei Dong; Yu Meng; Peixiang Ma; Wei Hou; Guang Yang
Journal:  Adv Sci (Weinh)       Date:  2022-07-19       Impact factor: 17.521

7.  Regioselective approach to colchiceine tropolone ring functionalization at C(9) and C(10) yielding new anticancer hybrid derivatives containing heterocyclic structural motifs.

Authors:  Krystian Pyta; Natalia Skrzypczak; Piotr Ruszkowski; Franz Bartl; Piotr Przybylski
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

Review 8.  Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.

Authors:  Paddy R A Melsen; Ryoji Yoshisada; Seino A K Jongkees
Journal:  Chembiochem       Date:  2022-02-18       Impact factor: 3.461
  8 in total

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