Gregory P Murphy1, Kirkpatrick B Fergus2, Thomas W Gaither2, Nima Baradaran2, Bryan B Voelzke3, Jeremy B Myers4, Bradley A Erickson5, Sean P Elliott6, Nejd F Alsikafi7, Alex J Vanni8, Jill C Buckley9, Benjamin N Breyer2. 1. Division of Urology, Washington University , St. Louis , Missouri. 2. Departments of Urology, University of California-San Francisco , San Francisco. 3. University of Washington , Seattle , Washington. 4. University of Utah , Salt Lake City , Utah. 5. University of Iowa , Iowa City , Iowa. 6. University of Minnesota , Minneapolis , Minnesota. 7. UroPartners , Gurnee , Illinois. 8. Lahey Hospital and Medical Center , Burlington , Massachusetts. 9. University of California-San Diego Health System , San Diego , California.
Abstract
PURPOSE: Perineal urethrostomy is a viable option for many complex urethral strictures. However, to our knowledge no comparison with anterior urethroplasty regarding patient reported outcome measures has been published. We compared these groups using a large multi-institution database. MATERIALS AND METHODS: We performed a retrospective study of anterior urethroplasty in the TURNS (Trauma and Urologic Reconstructive Network of Surgeons) database. The anterior urethroplasty cohort was defined by long strictures greater than 6 cm. We compared demographic, clinical, urinary and sexual characteristics using validated patient reported outcome measures between patients treated with long stricture anterior urethroplasty and those who underwent perineal urethrostomy. RESULTS: Of the 131 patients 92 treated with long stricture anterior urethroplasty and 39 treated with perineal urethrostomy met study inclusion criteria. The cumulative incidence of failure at 2 years was 30.2% (95% CI 18.3-47.3) for long stricture anterior urethroplasty and 14.5% (95% CI 4.8-39.1) for perineal urethrostomy (p = 0.09). Compared to baseline metrics, patients who underwent long stricture anterior urethroplasty and perineal urethrostomy had similar improvements in urinary function and stable sexual function after surgery. CONCLUSIONS: Patients reported improvement in urinary function after perineal urethrostomy with no deleterious effect on sexual function. These patient reported outcome measures were comparable to those of long stricture anterior urethroplasty. Perineal urethrostomy failure rates were similar to those of long stricture anterior urethroplasty.
PURPOSE: Perineal urethrostomy is a viable option for many complex urethral strictures. However, to our knowledge no comparison with anterior urethroplasty regarding patient reported outcome measures has been published. We compared these groups using a large multi-institution database. MATERIALS AND METHODS: We performed a retrospective study of anterior urethroplasty in the TURNS (Trauma and Urologic Reconstructive Network of Surgeons) database. The anterior urethroplasty cohort was defined by long strictures greater than 6 cm. We compared demographic, clinical, urinary and sexual characteristics using validated patient reported outcome measures between patients treated with long stricture anterior urethroplasty and those who underwent perineal urethrostomy. RESULTS: Of the 131 patients 92 treated with long stricture anterior urethroplasty and 39 treated with perineal urethrostomy met study inclusion criteria. The cumulative incidence of failure at 2 years was 30.2% (95% CI 18.3-47.3) for long stricture anterior urethroplasty and 14.5% (95% CI 4.8-39.1) for perineal urethrostomy (p = 0.09). Compared to baseline metrics, patients who underwent long stricture anterior urethroplasty and perineal urethrostomy had similar improvements in urinary function and stable sexual function after surgery. CONCLUSIONS:Patients reported improvement in urinary function after perineal urethrostomy with no deleterious effect on sexual function. These patient reported outcome measures were comparable to those of long stricture anterior urethroplasty. Perineal urethrostomy failure rates were similar to those of long stricture anterior urethroplasty.
Authors: Peter A S Johnstone; Hielke M de Vries; Juan Chipollini; G Daniel Grass; Franklin Boyd; Fernando Korkes; Maarten Albersen; Eduard Roussel; Yao Zhu; Ding-Wei Ye; Viraj Master; Thien-Linh Le; Asif Muneer; Oscar R Brouwer; Philippe E Spiess Journal: Clin Transl Radiat Oncol Date: 2021-08-09