Raimo K R Salokangas1, Frauke Schultze-Lutter2,3, Stefanie J Schmidt2,4, Henri Pesonen5, Sinikka Luutonen1,6, Paul Patterson7, Heinrich Graf von Reventlow8, Markus Heinimaa1, Tiina From1, Jarmo Hietala1,6. 1. Department of Psychiatry, University of Turku, Turku, Finland. 2. University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. 3. Medical Faculty, Department of Psychiatry and Psychotherapy, Heinrich-Heine University, Düsseldorf, Germany. 4. Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland. 5. Department of Mathematics, University of Turku, Turku, Finland. 6. Department of Psychiatry, Turku University Hospital, Turku, Finland. 7. Youthspace - Birmingham & Solihull Mental Health Foundation Trust, Birmingham, UK. 8. Nexus Klinik, Baden-Baden, Germany.
Abstract
Background: Childhood adversities and trauma (CAT) are associated with adult mental disorders. Nevertheless, although CAT of different domains mostly co-occurs, and co-morbidity is common, the associations between CAT and mental disorders, when taking these interrelations into account, are not well known.Aims: We aimed to study differential associations between the five core domains of CAT and current axis-I disorders, taking into consideration their interrelations. Methods: Four hundred and fifteen outpatients attending adult primary (n = 255) and psychiatric care (n = 160) were assessed with the Trauma and Distress Scale (TADS) and the Mini International Neuropsychiatric Interview (MINI). Associations between CAT core domains and diagnostic categories were examined by path analyses. Results: At least some infrequent experience of CAT (83.6%), mostly of neglect, and current mental disorders (49.4%), mostly depression, was frequent, as were co-morbidities and co-occurrence of CAT domains. Considering these interrelations in a path model of excellent fit, physical abuse predicted depressive, manic, psychotic and anxiety disorders, whereas emotional neglect predicted depressive, anxiety and substance misuse disorders.Conclusions: Of all five CAT core domains, physical abuse and emotional neglect had the strongest association with adult psychiatric disorders and might have transmitted earlier reported main effects of other CAT domains onto mental disorders.
Background: Childhood adversities and trauma (CAT) are associated with adult mental disorders. Nevertheless, although CAT of different domains mostly co-occurs, and co-morbidity is common, the associations between CAT and mental disorders, when taking these interrelations into account, are not well known.Aims: We aimed to study differential associations between the five core domains of CAT and current axis-I disorders, taking into consideration their interrelations. Methods: Four hundred and fifteen outpatients attending adult primary (n = 255) and psychiatric care (n = 160) were assessed with the Trauma and Distress Scale (TADS) and the Mini International Neuropsychiatric Interview (MINI). Associations between CAT core domains and diagnostic categories were examined by path analyses. Results: At least some infrequent experience of CAT (83.6%), mostly of neglect, and current mental disorders (49.4%), mostly depression, was frequent, as were co-morbidities and co-occurrence of CAT domains. Considering these interrelations in a path model of excellent fit, physical abuse predicted depressive, manic, psychotic and anxiety disorders, whereas emotional neglect predicted depressive, anxiety and substance misuse disorders.Conclusions: Of all five CAT core domains, physical abuse and emotional neglect had the strongest association with adult psychiatric disorders and might have transmitted earlier reported main effects of other CAT domains onto mental disorders.
Authors: Rachel Upthegrove; Paris Lalousis; Pavan Mallikarjun; Katharine Chisholm; Sian Lowri Griffiths; Mariam Iqbal; Mirabel Pelton; Renate Reniers; Alexandra Stainton; Marlene Rosen; Anne Ruef; Dominic B Dwyer; Marian Surman; Theresa Haidl; Nora Penzel; Lana Kambeitz-Llankovic; Alessandro Bertolino; Paolo Brambilla; Stefan Borgwardt; Joseph Kambeitz; Rebekka Lencer; Christos Pantelis; Stephan Ruhrmann; Frauke Schultze-Lutter; Raimo K R Salokangas; Eva Meisenzahl; Stephen J Wood; Nikolaos Koutsouleris Journal: Schizophr Bull Date: 2021-01-23 Impact factor: 9.306
Authors: Raimo K R Salokangas; Tiina From; Tuula Ilonen; Sinikka Luutonen; Markus Heinimaa; Reetta-Liina Armio; Heikki Laurikainen; Maija Walta; Janina Paju; Anna Toivonen; Päivi Jalo; Lauri Tuominen; Jarmo Hietala Journal: BMC Psychiatry Date: 2021-12-02 Impact factor: 3.630