Ali-Farid Safi1,2, Kathrin Grochau3,4, Uta Drebber4,5, Volker Schick4,6, Oliver Thiele7, Tim Backhaus3,4, Hans-Joachim Nickenig3,4, Joachim E Zöller3,4, Matthias Kreppel3,4. 1. Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany. asafi@outlook.de. 2. Center for Integrated Oncology Cologne-Bonn, Cologne, Germany. asafi@outlook.de. 3. Department for Oral and Craniomaxillofacial Plastic Surgery, University of Cologne, Kerpener Straße 62, 50931, Cologne, Germany. 4. Center for Integrated Oncology Cologne-Bonn, Cologne, Germany. 5. Department for Pathology, University of Cologne, Cologne, Germany. 6. Department for Anesthesiology and Intensive Care, University of Cologne, Cologne, Germany. 7. Department for Oral and Maxillofacial Plastic Surgery, Klinikum Ludwigshafen, Ludwigshafen, Germany.
Abstract
OBJECTIVES: Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters. MATERIALS AND METHODS: Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points. RESULTS: T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate. CONCLUSION: Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins. CLINICAL RELEVANCE: Our presented histoscore improves prediction of the overall survival of patients with OSCC.
OBJECTIVES: Tumor invasion into blood and/or lymphatic vessels, perineural invasion, and histopathological grading are evaluated to assess the biological aggressiveness of oral squamous cell carcinoma (OSCC). We aim to assess the prognostic impact of a novel scoring system, based upon the aforementioned histological parameters. MATERIALS AND METHODS: Retrospective chart review of 334 patients with treatment-naive squamous cell carcinoma of the oral cavity. Statistical analysis was performed using univariate and multivariate analysis. Histological grade G1 or G2 were assigned 0 points and G3 or G4 1 point. Invasion of the lymphatic vessels, blood vessels, or perineural space was given 1 point. Zero points were given, when invasion was not detectable. The final score was conducted through addition of each parameter. Therefore, our scoring system ranged between 0 and 4 points. RESULTS: T-classification (p < 0.001), N-classification (p < 0.001), UICC stage (p < 0.001), extracapsular spread (p < 0.001), locoregional recurrence (p < 0.001), and overall survival (p < 0.001) were significantly associated with the OSCC-Histoscore. In multivariate analysis, T-classification (p = 0.001), N-classification (p = 0.039), resection margins (p = 0.038), and OSCC-Histoscore (p < 0.001) were independent prognostic markers for overall survival rate. CONCLUSION: Our presented OSCC-Histoscore serves as a strong independent prognostic parameter for 5-year overall survival (OS) and predicts OS better than T-classification, N-classification, and resection margins. CLINICAL RELEVANCE: Our presented histoscore improves prediction of the overall survival of patients with OSCC.
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