Milagros Muthular1, Fernanda Bálsamo2, Pablo Passero1, Virginia Jewtuchowicz3, Valeria Miozza1, Marcelo Blanco Villalba4, María Isabel Brusca5, Cristina Pérez1. 1. Cátedra de Farmacología, Facultad de Odontología, Universidad de Buenos Aires, MT de Alvear 2142, Buenos Aires, Argentina. 2. Cátedra de Radiología, Facultad de Odontología, Universidad de Buenos Aires, MT de Alvear 2142, Buenos Aires, Argentina. 3. Dirección médica, Centro Médico Austral OMI, Montevideo 955, Buenos Aires, Argentina. 4. Cátedra de Microbiología, Facultad de Odontología, Universidad de Buenos Aires, MT de Alvear 2142, Buenos Aires, Argentina. 5. Cátedra de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Buenos Aires, Argentina.
Abstract
Candida albicans is involved in periodontal disease, which is influenced by sex hormones. AIM: To study the effects of the estrogen antagonist tamoxifen (TAM) on periodontal disease of oncological patients; clinical oral strains of C. albicans. PATIENTS: With periodontitis and breast cancer and other with AIDS were used. MATERIALS & METHODS: Periodontal disease was evaluated by the academy of periodontology procedures and the growth of clinical C. albicans isolates were evaluated by the Clinical and Laboratory Standards Institute techniques. RESULTS: Women who consumed TAM for more than 2 years decreased periodontitis severity. In vitro, TAM inhibited the growth of both fluconazole-sensitive and resistant C. albicans. CONCLUSION: Administered TAM chronically improves periodontal health and has antifungal activity on oral strains isolated from patients with odontologic and medical pathologies.
Candida albicans is involved in periodontal disease, which is influenced by sex hormones. AIM: To study the effects of the estrogen antagonist tamoxifen (TAM) on periodontal disease of oncological patients; clinical oral strains of C. albicans. PATIENTS: With periodontitis and breast cancer and other with AIDS were used. MATERIALS & METHODS: Periodontal disease was evaluated by the academy of periodontology procedures and the growth of clinical C. albicans isolates were evaluated by the Clinical and Laboratory Standards Institute techniques. RESULTS:Women who consumed TAM for more than 2 years decreased periodontitis severity. In vitro, TAM inhibited the growth of both fluconazole-sensitive and resistant C. albicans. CONCLUSION: Administered TAM chronically improves periodontal health and has antifungal activity on oral strains isolated from patients with odontologic and medical pathologies.
Authors: Jemima Ho; Giorgio Camilli; James S Griffiths; Jonathan P Richardson; Nessim Kichik; Julian R Naglik Journal: Immunology Date: 2020-09-13 Impact factor: 7.397