Juandi Zhou1, Jia Song2, Shijin Gong3, Weihang Hu3, Minjia Wang3, Aibing Xiao4, Cong Zhang5, Zhouzhou Dong6. 1. Department of General Surgery, Zhejiang Hospital, Hangzhou, China. 2. Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, China. songjia9a@163.com. 3. Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou, China. 4. Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, China. 5. Zhejiang Chinese Medical University, Hangzhou, China. 6. Department of Critical Care Medicine, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo, China.
Abstract
BACKGROUND: Lung ultrasound is a valuable imaging tool in the diagnosis of community-acquired pneumonia. However, its diagnostic accuracy in ventilator-associated pneumonia (VAP) has not been fully investigated. The aim of this study was to evaluate the diagnostic performance of the combination of a lung ultrasound with procalcitonin (PCT) in mechanically ventilated subjects with symptoms suggestive of pneumonia. METHODS: A prospective study of 124 subjects with suspected VAP in 2 multidisciplinary ICUs was conducted between December 2016 and October 2017. Lower respiratory tract specimens were collected from all the subjects at enrollment and on the following 3 d. PCT assays were performed within 1 h of enrollment. Lung ultrasound and then computed tomography of the chest were performed within 24 h to detect lung consolidations. The subjects were divided into VAP and non-VAP groups according to the results of a computed tomography of the chest and semi-quantitative culture of the lower respiratory tract sample. RESULTS: A total of 124 subjects were included (48 in the VAP group and 76 in the non-VAP group). A positive lung ultrasound result combined with PCT of ≥0.25 ng/mL diagnosed VAP, with a sensitivity and specificity of 81.3 and 85.5%, respectively. The area under the receiver operating characteristic curve was significantly higher for lung ultrasound combined with PCT than for a white blood cell count, PCT, C-reactive protein, or Clinical Pulmonary Infection Score alone. CONCLUSIONS: A combination of lung ultrasound and PCT was accurate in the diagnosis of VAP. Lung ultrasound is a useful lung-imaging tool to assist VAP diagnosis.
BACKGROUND: Lung ultrasound is a valuable imaging tool in the diagnosis of community-acquired pneumonia. However, its diagnostic accuracy in ventilator-associated pneumonia (VAP) has not been fully investigated. The aim of this study was to evaluate the diagnostic performance of the combination of a lung ultrasound with procalcitonin (PCT) in mechanically ventilated subjects with symptoms suggestive of pneumonia. METHODS: A prospective study of 124 subjects with suspected VAP in 2 multidisciplinary ICUs was conducted between December 2016 and October 2017. Lower respiratory tract specimens were collected from all the subjects at enrollment and on the following 3 d. PCT assays were performed within 1 h of enrollment. Lung ultrasound and then computed tomography of the chest were performed within 24 h to detect lung consolidations. The subjects were divided into VAP and non-VAP groups according to the results of a computed tomography of the chest and semi-quantitative culture of the lower respiratory tract sample. RESULTS: A total of 124 subjects were included (48 in the VAP group and 76 in the non-VAP group). A positive lung ultrasound result combined with PCT of ≥0.25 ng/mL diagnosed VAP, with a sensitivity and specificity of 81.3 and 85.5%, respectively. The area under the receiver operating characteristic curve was significantly higher for lung ultrasound combined with PCT than for a white blood cell count, PCT, C-reactive protein, or Clinical Pulmonary Infection Score alone. CONCLUSIONS: A combination of lung ultrasound and PCT was accurate in the diagnosis of VAP. Lung ultrasound is a useful lung-imaging tool to assist VAP diagnosis.
Authors: P H Mayo; R Copetti; D Feller-Kopman; G Mathis; E Maury; S Mongodi; F Mojoli; G Volpicelli; M Zanobetti Journal: Intensive Care Med Date: 2019-08-15 Impact factor: 17.440
Authors: Carmina Guitart; Esther Esteban; Judit Becerra; Javier Rodríguez-Fanjul; Francisco José Cambra; Mònica Balaguer; Iolanda Jordan Journal: Pediatr Res Date: 2021-12-30 Impact factor: 3.953