Literature DB >> 30670430

DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa.

Manoj Kumar1, Madhvi Rao2, Kedar P Purnapatre2, Tarani Kanta Barman2, Vattan Joshi2, Amuliya Kashyap2, Tridib Chaira3, Ramesh B Bambal3, Manisha Pandya2, Souhaila Al Khodor4, Dilip J Upadhyay2,5, Nobuhisa Masuda2.   

Abstract

DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistant Pseudomonas aeruginosa isolated from clinical samples and in vitro biofilms. In a murine catheter-associated urinary tract infection model, DS86760016 treatment resulted in significant eradication of P. aeruginosa from the kidney, bladder, and catheter without developing drug resistance. Our data suggest that DS86760016 has the potential to act as a new drug for the treatment of Pseudomonas infections.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Gram-negative bacteria; Pseudomonas aeruginosazzm321990; UTI; aminoacyl-tRNA synthesis; multidrug resistance

Mesh：

Substances：

Year:  2019        PMID： 30670430      PMCID： PMC6437482          DOI： 10.1128/AAC.02122-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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Review 3.  Catheter-associated urinary tract infections.

Authors:  J W Warren
Journal:  Int J Antimicrob Agents       Date:  2001-04       Impact factor: 5.283

Review 4.  Pseudomonas aeruginosa biofilms in disease.

Authors:  Lawrence R Mulcahy; Vincent M Isabella; Kim Lewis
Journal:  Microb Ecol       Date:  2013-10-06       Impact factor: 4.552

5.  Overview of nosocomial infections caused by gram-negative bacilli.

Authors:  Robert Gaynes; Jonathan R Edwards
Journal:  Clin Infect Dis       Date:  2005-08-16       Impact factor: 9.079

6.  Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosis.

Authors:  Samuel M Moskowitz; Jessica M Foster; Julia Emerson; Jane L Burns
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

Review 7.  Ventilator associated pneumonia.

Authors:  J D Hunter
Journal:  Postgrad Med J       Date:  2006-03       Impact factor: 2.401

8.  An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Authors:  Fernando L Rock; Weimin Mao; Anya Yaremchuk; Mikhail Tukalo; Thibaut Crépin; Huchen Zhou; Yong-Kang Zhang; Vincent Hernandez; Tsutomu Akama; Stephen J Baker; Jacob J Plattner; Lucy Shapiro; Susan A Martinis; Stephen J Benkovic; Stephen Cusack; M R K Alley
Journal:  Science       Date:  2007-06-22       Impact factor: 47.728

9.  Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase.

Authors:  Qing-Hua Hu; Ru-Juan Liu; Zhi-Peng Fang; Jiong Zhang; Ying-Ying Ding; Min Tan; Meng Wang; Wei Pan; Hu-Chen Zhou; En-Duo Wang
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

10.  Macrolides decrease the minimal inhibitory concentration of anti-pseudomonal agents against Pseudomonas aeruginosa from cystic fibrosis patients in biofilm.

Authors:  Larissa Lutz; Dariane Castro Pereira; Rodrigo Minuto Paiva; Alexandre Prehn Zavascki; Afonso Luis Barth
Journal:  BMC Microbiol       Date:  2012-09-08       Impact factor: 3.605
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  2 in total

1.  Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model.

Authors:  Manoj Kumar; Madhvi Rao; Tarun Mathur; Tarani Kanta Barman; Vattan Joshi; Tridib Chaira; Smita Singhal; Manisha Pandya; Souhaila Al Khodor; Dilip J Upadhyay; Nobuhisa Masuda
Journal:  Front Microbiol       Date:  2021-04-23       Impact factor: 5.640

2.  Clinical Efficacy and In Vitro Drug Sensitivity Test Results of Azithromycin Combined With Other Antimicrobial Therapies in the Treatment of MDR P. aeruginosa Ventilator-Associated Pneumonia.

Authors:  Yuqin Huang; Wenguo Wang; Qiang Huang; Zhengyan Wang; Zhuanzhuan Xu; Chaochao Tu; Dongli Wan; Miaobo He; Xiaoyi Yang; Huaqiang Xu; Hanqin Wang; Ying Zhao; Mingli Tu; Quan Zhou
Journal:  Front Pharmacol       Date:  2022-08-10       Impact factor: 5.988
  2 in total

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