Literature DB >> 30668950

Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

Jonathan Downar1.   

Abstract

Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies.
Copyright © 2018 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 30668950     DOI： 10.1016/j.cub.2018.11.057

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  7 in total

1.  Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice.

Authors:  Hiroshi Kuniishi; Yuko Nakatake; Masayuki Sekiguchi; Mitsuhiko Yamada
Journal:  Neuropsychopharmacology       Date:  2022-06-13       Impact factor: 8.294

2.  Large-scale structural network change correlates with clinical response to rTMS in depression.

Authors:  Daniel M Blumberger; Jonathan Downar; Sean M Nestor; Arsalan Mir-Moghtadaei; Fidel Vila-Rodriguez; Peter Giacobbe; Zafiris J Daskalakis
Journal:  Neuropsychopharmacology       Date:  2022-02-02       Impact factor: 8.294

3.  Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression.

Authors:  Junyan Wang; Penghong Liu; Aixia Zhang; Chunxia Yang; Sha Liu; Jizhi Wang; Yong Xu; Ning Sun
Journal:  Front Hum Neurosci       Date:  2021-01-11       Impact factor: 3.169

4.  Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression.

Authors:  Dan Dai; Cheryl M Lacadie; Sophie E Holmes; Ryan Cool; Alan Anticevic; Chris Averill; Chadi Abdallah; Irina Esterlis
Journal:  Chronic Stress (Thousand Oaks)       Date:  2020-12-22

5.  "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases as MAINTENANCE Network Dysfunctions through Insights from slMFB DBS in Depression and Obsessive-Compulsive Disorder.

Authors:  Volker A Coenen; Thomas E Schlaepfer; Bastian E A Sajonz; Peter C Reinacher; Máté D Döbrössy; Marco Reisert
Journal:  Brain Sci       Date:  2022-03-25

6.  A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression.

Authors:  Rongrong Du; Qian Zhou; Tianzheng Hu; Jinmei Sun; Qiang Hua; Yingru Wang; Yuanyuan Zhang; Kongliang He; Yanghua Tian; Gong-Jun Ji; Kai Wang
Journal:  Front Psychol       Date:  2022-09-02

7.  Personalized connectivity-guided DLPFC-TMS for depression: Advancing computational feasibility, precision and reproducibility.

Authors:  Robin F H Cash; Luca Cocchi; Jinglei Lv; Yumeng Wu; Paul B Fitzgerald; Andrew Zalesky
Journal:  Hum Brain Mapp       Date:  2021-02-05       Impact factor: 5.038
  7 in total

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