OBJECTIVES: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). METHODS: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion. RESULTS: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs. CONCLUSION: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
OBJECTIVES: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). METHODS: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion. RESULTS: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs. CONCLUSION: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
Authors: C R Jack; M M Shiung; S D Weigand; P C O'Brien; J L Gunter; B F Boeve; D S Knopman; G E Smith; R J Ivnik; E G Tangalos; R C Petersen Journal: Neurology Date: 2005-10-25 Impact factor: 9.910
Authors: Yaakov Stern; Eric Zarahn; Christian Habeck; Roee Holtzer; Brian C Rakitin; Arjun Kumar; Joseph Flynn; Jason Steffener; Truman Brown Journal: Cereb Cortex Date: 2007-08-03 Impact factor: 5.357
Authors: Nicolas Cherbuin; Erin I Walsh; Liana Leach; Anne Brüstle; Richard Burns; Kaarin J Anstey; Perminder S Sachdev; Bernhard T Baune Journal: Biomedicines Date: 2022-05-26