Literature DB >> 3066849

Trial of ganglioside GM1 in acute stroke.

B I Hoffbrand1, P J Bingley, S M Oppenheimer, C D Sheldon.   

Abstract

Ganglioside GM1 (100 mg) was given daily by intramuscular injection for 28 days in a double-blind placebo controlled trial of acute stroke. No significant difference was detected in a 6 month follow-up period between well matched control and active groups. Although the number of patients studied was small the findings are believed to indicate that GM1 is unlikely to be of value in the treatment of acute stroke in the dose and route of administration used.

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Year:  1988        PMID: 3066849      PMCID: PMC1033029          DOI: 10.1136/jnnp.51.9.1213

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  4 in total

1.  Effects of GM1 ganglioside in cerebrovascular diseases: a double-blind trial in 40 cases.

Authors:  L Battistin; A Cesari; F Galligioni; G Marin; M Massarotti; D Paccagnella; A Pellegrini; G Testa; P Tonin
Journal:  Eur Neurol       Date:  1985       Impact factor: 1.710

2.  When was a "negative" clinical trial big enough? How many patients you needed depends on what you found.

Authors:  A S Detsky; D L Sackett
Journal:  Arch Intern Med       Date:  1985-04

3.  [Development of a neurological score for the clinical evaluation of sylvian infarctions].

Authors:  J M Orgogozo; R Capildeo; C N Anagnostou; O Juge; J J Péré; J F Dartigues; T J Steiner; A Yotis; F C Rose
Journal:  Presse Med       Date:  1983-12-29       Impact factor: 1.228

4.  Double-blind evaluation of monosialoganglioside (GM1) therapy in stroke.

Authors:  S Bassi; M G Albizzati; M Sbacchi; L Frattola; M Massarotti
Journal:  J Neurosci Res       Date:  1984       Impact factor: 4.164

  4 in total
  6 in total

1.  Trial of ganglioside GM1 in acute stroke.

Authors:  I Appollonio; L Frattola; M Massarotti
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-05       Impact factor: 10.154

Review 2.  Limiting neurological damage after stroke: a review of pharmacological treatment options.

Authors:  S J Read; T Hirano; S M Davis; G A Donnan
Journal:  Drugs Aging       Date:  1999-01       Impact factor: 3.923

3.  The Therapeutic Role of Gangliosides in Neurological Disorders.

Authors:  J S Schneider
Journal:  CNS Drugs       Date:  1994-03       Impact factor: 5.749

Review 4.  Is ganglioside GM1 effective in the treatment of stroke?

Authors:  S Braune
Journal:  Drugs Aging       Date:  1991-01       Impact factor: 3.923

Review 5.  Mechanisms and management of stroke in the elderly.

Authors:  A Shuaib; V C Hachinski
Journal:  CMAJ       Date:  1991-09-01       Impact factor: 8.262

Review 6.  Gangliosides: Treatment Avenues in Neurodegenerative Disease.

Authors:  Pierre J Magistretti; Fred H Geisler; Jay S Schneider; P Andy Li; Hubert Fiumelli; Simonetta Sipione
Journal:  Front Neurol       Date:  2019-08-06       Impact factor: 4.003

  6 in total

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