| Literature DB >> 30666877 |
Gahzaleh Jahanshah1,2, Qing Yan3, Heike Gerhardt4,5, Zoltán Pataj4,5, Michael Lämmerhofer4,5, Isabelle Pianet6, Michaele Josten7,8, Hans-Georg Sahl7,8, Mark W Silby9, Joyce E Loper3,10, Harald Gross1,2.
Abstract
Genome mining of the Gram-negative bacterium Pseudomonas fluorescens Pf0-1 showed that the strain possesses a silent NRPS-based biosynthetic gene cluster encoding a new lipopeptide; its activation required the repair of the global regulator system. In this paper, we describe the genomics-driven discovery and characterization of the associated secondary metabolite gacamide A, a lipodepsipeptide that forms a new family of Pseudomonas lipopeptides. The compound has a moderate, narrow-spectrum antibiotic activity and facilitates bacterial surface motility.Entities:
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Year: 2019 PMID： 30666877 DOI： 10.1021/acs.jnatprod.8b00747
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050