José Ríos-Díaz1,2, María Elena Del Baño-Aledo3, José I Tembl-Ferrairó4, Maria J Chumillas4,5,6, Juan F Vázquez-Costa5,6,7, Jacinto J Martínez-Payá8. 1. Centro de Ciencias de la Salud San Rafael, Universidad Antonio de Nebrija, Paseo de la Habana 70 bis, 28036, Madrid, Spain. 2. Fundación San Juan de Dios, Madrid, Spain. 3. Physiotherapy Department, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain. mbano@um.es. 4. Department of Neurophysiology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 5. Neuromuscular and Ataxias Research Unit, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain. 6. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Valencia, Spain. 7. Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 8. Physiotherapy Department, Facultad de Medicina, Universidad de Murcia, Campus de Espinardo, 30100, Murcia, Spain.
Abstract
OBJECTIVES: To assess the differences in morphological and texture parameters of median nerve (MN) and abductor pollicis brevis (APB) between amyotrophic lateral sclerosis (ALS) patients and controls. METHODS: The cross-sectional area (CSA) of the MN and the muscle thickness (MTh) of APB were measured bilaterally in 59 recently diagnosed ALS patients and 20 matched healthy controls. Echointensity (EI), echovariation (EV) and grey-level co-occurrence matrix (GLCM) texture features of both structures were also analysed. Correlations between these parameters and clinical variables (muscle strength and disability) were analysed. RESULTS: The CSA of MN was significantly lower in ALS patients (MD = - 1.83 mm2 [95% CI = 2.89; - 0.77 mm2]; p = 0.01). ALS patients showed significantly lower MTh (- 2.23 mm [3.16; - 1.30 mm]; p < 0.001) and EV (- 7.40 [11.5; - 3.33]; p = 0.004) and higher EI (21.2 [11.9; 30.6]; p < 0.001) in the APB muscle. No relevant differences were detected in GLCM features for this muscle. The model including all parameters (CSA for MN and MTh, EI and EV for APB) showed an AUC of 82% (sensitivity 87%; specificity 42%). Muscle strength and disability correlated with APB muscle ultrasound parameters but not with those of the MN. CONCLUSIONS: APB muscle ultrasound biomarkers (especially MTh and EI) showed better discrimination capacity and correlation with clinical variables than MN biomarkers. However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and progression monitoring in ALS. KEY POINTS: • Abductor pollicis brevis muscle and median nerve impairment is detectable by ultrasound in amyotrophic lateral sclerosis patients, even in those without clinical impairment. • Muscle ultrasound biomarkers show better discrimination capacity than nerve biomarkers in amyotrophic lateral sclerosis. • Quantitative neuromuscular ultrasound biomarkers could be useful in a general amyotrophic lateral sclerosis population early on the disease.
OBJECTIVES: To assess the differences in morphological and texture parameters of median nerve (MN) and abductor pollicis brevis (APB) between amyotrophic lateral sclerosis (ALS) patients and controls. METHODS: The cross-sectional area (CSA) of the MN and the muscle thickness (MTh) of APB were measured bilaterally in 59 recently diagnosed ALSpatients and 20 matched healthy controls. Echointensity (EI), echovariation (EV) and grey-level co-occurrence matrix (GLCM) texture features of both structures were also analysed. Correlations between these parameters and clinical variables (muscle strength and disability) were analysed. RESULTS: The CSA of MN was significantly lower in ALSpatients (MD = - 1.83 mm2 [95% CI = 2.89; - 0.77 mm2]; p = 0.01). ALSpatients showed significantly lower MTh (- 2.23 mm [3.16; - 1.30 mm]; p < 0.001) and EV (- 7.40 [11.5; - 3.33]; p = 0.004) and higher EI (21.2 [11.9; 30.6]; p < 0.001) in the APB muscle. No relevant differences were detected in GLCM features for this muscle. The model including all parameters (CSA for MN and MTh, EI and EV for APB) showed an AUC of 82% (sensitivity 87%; specificity 42%). Muscle strength and disability correlated with APB muscle ultrasound parameters but not with those of the MN. CONCLUSIONS:APB muscle ultrasound biomarkers (especially MTh and EI) showed better discrimination capacity and correlation with clinical variables than MN biomarkers. However, the combination of both biomarkers increased their ability to detect LMN impairment, suggesting that both biomarkers could be used in a complementary manner for the diagnosis and progression monitoring in ALS. KEY POINTS: • Abductor pollicis brevis muscle and median nerve impairment is detectable by ultrasound in amyotrophic lateral sclerosispatients, even in those without clinical impairment. • Muscle ultrasound biomarkers show better discrimination capacity than nerve biomarkers in amyotrophic lateral sclerosis. • Quantitative neuromuscular ultrasound biomarkers could be useful in a general amyotrophic lateral sclerosis population early on the disease.
Authors: Ilse M P Arts; Frank G van Rooij; Sebastiaan Overeem; Sigrid Pillen; Henny M H A Janssen; H Jurgen Schelhaas; Machiel J Zwarts Journal: Ultrasound Med Biol Date: 2007-10-26 Impact factor: 2.998
Authors: Adrian Escriche-Escuder; Manuel Trinidad-Fernández; Bella Pajares; Marcos Iglesias-Campos; Emilio Alba; José Manuel García-Almeida; Cristina Roldán-Jiménez; Antonio I Cuesta-Vargas Journal: Sci Rep Date: 2022-09-07 Impact factor: 4.996
Authors: Lorena Canosa-Carro; Daniel López-López; Carmen de Labra; Raquel Díaz-Meco-Conde; Blanca de-la-Cruz-Torres; Carlos Romero-Morales Journal: Healthcare (Basel) Date: 2022-03-14